143993-07-1

Basic information

• Product Name: 2-CYCLOHEXYL-2-HYDROXY-N-PHENYLACETAMIDE
• Synonyms: 2-CYCLOHEXYL-2-HYDROXY-N-PHENYLACETAMIDE
• CAS NO: 143993-07-1
• Molecular Formula: C14H19NO2
• Molecular Weight: 233.31
• Mol File: 143993-07-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CYCLOHEXYL-2-HYDROXY-N-PHENYLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYCLOHEXYL-2-HYDROXY-N-PHENYLACETAMIDE(143993-07-1)
• EPA Substance Registry System: 2-CYCLOHEXYL-2-HYDROXY-N-PHENYLACETAMIDE(143993-07-1)

Safety Data

• Hazardous Substances Data: 143993-07-1(Hazardous Substances Data)

Upstream product

• 1197040-29-1 phenyl isocyanate 
• 2043-61-0 cyclohexanecarbaldehyde 

Relevant articles and documents

Copper-catalyzed oxidative cleavage of Passerini and Ugi adducts in basic medium yielding α-ketoamides

The aerobic oxidative cleavage of Passerini and Ugi adducts in the presence of base and copper(i) iodide is studied in detail. The oxidative cleavage yields α-ketoamides along with acids and amides from Passerini and Ugi adducts respectively. Mechanistic investigations revealed that the reaction proceeds via a radical pathway involving molecular oxygen. Control experiments with 18O-labeled Passerini adducts confirmed that molecular oxygen is the source of oxygen in α-ketoamides. A variety of Passerini and Ugi adducts were studied to explore the effect of substitution. Overall, the present study provides an insight into the reactivity of Passerini and Ugi adducts in strong basic conditions along with a method to prepare α-ketoamides.