143993-12-8 Usage
Uses
2-[(Methylamino)methyl]-3,4-dihydroquinazolin-4-one is used as a reactant in the preparation of potent inhibitors of hedgehog signaling pathway.
Check Digit Verification of cas no
The CAS Registry Mumber 143993-12-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,9,9 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 143993-12:
(8*1)+(7*4)+(6*3)+(5*9)+(4*9)+(3*3)+(2*1)+(1*2)=148
148 % 10 = 8
So 143993-12-8 is a valid CAS Registry Number.
143993-12-8Relevant articles and documents
Potent inhibitors of the Hedgehog signaling pathway
Brunton, Shirley A.,Stibbard, John H. A.,Rubin, Lee L.,Kruse, Lawrence I.,Guicherit, Oivin M.,Boyd, Edward A.,Price, Steven
, p. 1108 - 1110 (2008/09/19)
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.