143993-24-2Relevant academic research and scientific papers
Nitrogen Bridgehead Compounds Part 90. An Efficient Versatile Synthesis of 1-methyl-2-substituted 1,2,3,4-tetrahydro-6H-pyrazinoquinazoline-3,6-diones
Koekoesi, Jozsef,Almasi, Janos,Podanyi, Benjamin,Feher, Miklos,Boecskei, Zsolt,et al.
, p. 1851 - 1866 (2007/10/03)
A versatile synthesis of 2-substituted 1-methyl- and 1,4-dimethyl-1,2,3,4-tetrahydro-6H-pyrazinoquinazoline-3,6-diones is presented, starting from 2-(1-bromoethyl)quinazolin-4(3H)-one.The key step of the reaction sequence is the diastereoselective cyclization of 2-ethyl>quinazolin-4(3H)-ones.Usually 1,4-dimethyl derivatives are obtained as pure racemic cis-compounds (2-alkyl and 2-benzyl derivatives, or a mixture of diastereomers, containing the 4-methyl group in quasiaxial position.
Nitrogen Bridgehead Compounds. Part 88 [1]. Synthesis of 3H, 7H-[1,4]Diazepino[3,4-b]quinazoline-3,7-diones
Szabo, Monika,Koekoesi, Jozsef,Oerfi, Laszlo,Kovacs, Attila,Hermecz, Istvan
, p. 21 - 25 (2007/10/03)
3H,7H-[1,4]Diazepino[3,4-b]quinazolone-3,7-diones 9, 11 were synthesized starting from 2-(1-bromoethyl)quinazolin-4(3H)-ones 3 and 17 via 2-[1-(4-methoxyphenylamino)ethyl]quinazolin-4(3H)-ones 4 and 18. Cyclization of 3-[2-(1-bromoethyl)-4-oxo-3,4-dihydroquinazolin-3-yl)propionic acid 14 by the action of triethylamine provided the first representative of the tricyclic 7H-[1,4]oxazepino[3,4-b]quinazoline-3,7-dione system, compound 15. The new tricyclic derivatives 9, 11 and 15 are characterized by uv, ir and 1H nmr spectroscopy.
Stereoselective synthesis of a 2,3-disubstituted 5-pyr-rolidinone derivative of quinazolin-4(3H)-one
Szabó, Mónika,K?k?si, József,Kovács, Attila,B?cskei, Zsolt,Hermecz, István
, p. 2437 - 2442 (2007/10/03)
Thermal cyclization of acetoacetamide (3), prepared from 2-[1'-(p-methoxyphenylaminoethyl]quinazolin-4(3H)-one (2) and ethyl acetoacetate, resulted in the formation of 2-(5-oxopyrrolidin-2-yl)quinazolin-4(3H)-one (6) with high selectivity in excellent yie
