143994-94-9

Basic information

• Product Name: 17-N-<4-(1-azi-2,2,2-trifluoroethyl)>-benzyliminograyanotox-15-ene-3β,5,6β,14R-tetraol
• CAS NO: 143994-94-9
• Molecular Weight: 549.634
• Mol File: 143994-94-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 17-N-<4-(1-azi-2,2,2-trifluoroethyl)>-benzyliminograyanotox-15-ene-3β,5,6β,14R-tetraol(CAS DataBase Reference)
• NIST Chemistry Reference: 17-N-<4-(1-azi-2,2,2-trifluoroethyl)>-benzyliminograyanotox-15-ene-3β,5,6β,14R-tetraol(143994-94-9)
• EPA Substance Registry System: 17-N-<4-(1-azi-2,2,2-trifluoroethyl)>-benzyliminograyanotox-15-ene-3β,5,6β,14R-tetraol(143994-94-9)

Safety Data

• Hazardous Substances Data: 143994-94-9(Hazardous Substances Data)

Upstream product

• 92367-11-8 3-[4'-(bromomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine 
• 143994-95-0 17-amino-grayanotox-15-ene-3β,5,6β,14R-tetraol 

Relevant articles and documents

Synthesis of the Photoaffinity-labeled Grayanotoxins for Studying the Gating Mechanism of Na Channel

Grayanotoxin loosely binds to the neurotoxin receptor site 2 on Na channels. 14R-N-benzyliminograyanotoxane-3β,5,6β,16-tetraol (4) and 17-N-benzyliminograyanotox-15-ene-3β,5,6β,14R-tetraol (5) were synthesized and applied intracellularly to squid axons.On UV irradiation, their membrane potential produced by a dose of 4 or 5 rose to higher level than that in the dark.However, in the case of 5, even when the axons were internally perfused with toxin-free solution after the dose, the potential level didnot fall in contrast to 4.It suggested that 5 covalently bound to the receptor involved in the gating mechanism of Na channels.