143994-97-2

Upstream product

• 3970-21-6 2-Methoxyethoxymethyl chloride 
• 144069-03-4 (+)-(1α,2β,3α)-1-acetoxy-2-<(phenylmethoxy)methyl>cyclopent-4-en-3-ol 
• 143994-96-1 Acetic acid (1R,2R,3S,4S,5S)-3-benzyloxymethyl-4-hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl ester 
• 134756-61-9 (1α,2β,3α)-2-<(benzyloxy)methyl>-4-cyclopentene-1,3-diol diacetate 

Relevant academic research and scientific papers

Enzyme-catalysed Hydrolysis of 3,5-cis-Diacetoxy-4-trans-benzyloxymethylcyclopentene and the Synthesis of Aristeromycin Precursors

The optically active mono-ester 2 was obtained by enzyme-catalysed hydrolysis of the diester 1 and converted into the azide 8 and the amine 13, synthetic precursors of (+)- and (-)-aristeromycin.

Enzyme-Catalysed Hydrolyses of Some Meso-Diesters

The diester 7 is hydrolysed, using porcine pancreatic lipase as catalyst, to give the monoester 8.The latter compound has been converted into the known azido alcohol 9 and into the purine derivative 10.Pig liver esterase (ple) catalysed hydrolysis of the diester 11 gave the acid 13 not the enantiomer 12 as previously reported.The structure of 13 was determined by its conversion into the compound ent-10.The diesters 17 and 18 are converted into the mono-esters 20 and 21 respectively using ple: hydrolysis of the diester 16 yields a mono-acid of high optical purity.The structure of this mono-acid is believed to be that shown in formula 19.