143999-89-7 Usage
Chemical structure
The compound consists of a piperazine ring attached to a benzene ring with a methyl group and an acetyl group.
Form
It is found in the form of a hydrochloride salt.
Potential use
It has been studied for its potential use as a pharmaceutical agent.
Field of application
Particularly in the field of central nervous system disorders.
Researched conditions
It has been researched as a potential treatment for conditions such as depression, anxiety, and schizophrenia.
Mechanism of action
Its chemical structure and properties make it a potential candidate for modulating neurotransmitter activity in the brain.
Further research
More research is necessary to fully understand its safety and efficacy for these applications.
Check Digit Verification of cas no
The CAS Registry Mumber 143999-89-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,9,9 and 9 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 143999-89:
(8*1)+(7*4)+(6*3)+(5*9)+(4*9)+(3*9)+(2*8)+(1*9)=187
187 % 10 = 7
So 143999-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C13H18N2O2.ClH/c1-11-2-4-12(5-3-11)17-10-13(16)15-8-6-14-7-9-15;/h2-5,14H,6-10H2,1H3;1H
143999-89-7Relevant articles and documents
Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents
Zhong, Yan,Xu, Yi,Zhang, Ai-Xia,Li, Xiao-Feng,Xu, Zhao-Ying,Li, Ping,Wu, Bin
, p. 2526 - 2530 (2016/07/07)
A series of new aryloxyacetamide derivatives 10a-s and 14a-m are designed and synthesized. Their protective activities against the glutamate-induced cell death were investigated in differentiated rat pheochromocytoma cells (PC12 cells). Most compounds exhibited neuroprotective effects, especially for 10m, 10r, 14b and 14c, which showed potential protection of PC12 cells at three doses (0.1, 1.0, 10 μM). MTT assay, Hoechst 33342/PI double staining, and high content screening (HCS) revealed that pretreatment of the cells with 10m, 10r, 14b and 14c has significantly decreased the extent of cell apoptosis in a dose-dependent manner. The results of western blot analysis demonstrated these compounds suppressed apoptosis of glutamate-induced PC12 cells via caspase-3 pathway. These compounds can be lead compounds for further discovery of neuroprotective agents for treating cerebral ischemic stroke. Basic structure-activity relationships are also presented.