144-12-7 Usage
Uses
Used in Pharmaceutical Industry:
TIEMONIUM IODIDE is used as an active ingredient in the treatment of urinary incontinence. It is combined with bicifadine to create compositions that help manage and alleviate the symptoms of this condition. The use of TIEMONIUM IODIDE in these compositions is due to its effectiveness in addressing the underlying issues that contribute to urinary incontinence, making it a valuable component in the development of pharmaceutical solutions for this medical concern.
Originator
Visceralgine,Riom,France,1963
Manufacturing Process
(a) N-(3-hydroxy-3-phenyl-3-α-thienyl-propyl) morpholine was first prepared:
The following quantities of reactants were mixed in a 2-liter balloon flask
having 3 tubes fitted respectively with a mercury-sealed agitator, a reflux
condenser having a calcium chloride seal, and a dropping funnel:
Magnesium turnings 27 g (1.1 g at. wt)
Bromobenzene 181 g (1.15 mol)
Anhydrous ether 500 cc
(b) To the cold Grignard solution was added a solution containing:
Thienyl-morpholinoethyl ketone 180 g (0.8 mol)
Anhydrous ether 250 cc
The ketone, preferably prepared by a Grignard reaction, was added in such a
way as to maintain the ether under constant reflux. When all of the solution
had been added, the mixture was refluxed for a further hour. The mixture was
then allowed to stand for 12 hours at ambient temperature, after which the
reaction mass was extracted with ice and ammonium chloride in known
manner.
(c) The ether solution was treated with 2 N hydrochloric acid solution and the
amino-alcohol was obtained as the hydrochloride (yield approximately 60%);
it was purified by recrystallization from methanol.
The resulting product was dissolved in water, made alkaline with dilute
NH4OHand was extracted with ether. After evaporation of the ether, the
amino-alcohol was obtained as a base.
(d) To prepare the quaternary ammonium iodide, the amino-alcohol above
was dissolved in a minimum amount of anhydrous ether and was treated with
its own weight of methyl iodide. A well-crystallized product was obtained and
was washed with anhydrous ether. (Melting point 189°C to 191°C).
Therapeutic Function
Spasmolytic, Anticholinergic
Check Digit Verification of cas no
The CAS Registry Mumber 144-12-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 4 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 144-12:
(5*1)+(4*4)+(3*4)+(2*1)+(1*2)=37
37 % 10 = 7
So 144-12-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H24NO2S.HI/c1-19(11-13-21-14-12-19)10-9-18(20,17-8-5-15-22-17)16-6-3-2-4-7-16;/h2-8,15,20H,9-14H2,1H3;1H/q+1;/p-1
