PIPERAZINE CITRATE is an organic compound with a six-membered ring containing two opposing nitrogen atoms, primarily used as an anthelmintic agent and for reducing blood pressure. It was first introduced as an anthelmintic in 1953 and has the remarkable ability to dissolve uric acid, producing a soluble urate. Piperazine citrate is a white, crystalline powder with a slight odor, soluble in water, and insoluble in alcohol and ether.
144-29-6
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Basic information
- Product Name: PIPERAZINE CITRATE
- Synonyms: ANTEPAR;CITRIC ACID SESQUIPIPERAZINE SALT;PIPERAZINE CITRATE;PIPERAZINE CITRATE SALT;PARAZINE;TRIPIPERAZINE DICITRATE;PiperazineCitrateBp;Tripiperazindicitrat
- CAS NO:144-29-6
- Molecular Formula: C4H10N2*C6H8O7
- Molecular Weight: 642.65
- EINECS: 205-622-8
- Product Categories: Piperidines, Piperidones, Piperazines;API
- Mol File: 144-29-6.mol
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Chemical Properties
- Melting Point: 183-187℃
- Boiling Point: 812.2 °C at 760 mmHg
- Flash Point: 445 °C
- Appearance: White crystalline powder
- Density: 0.741[at 20℃]
- Vapor Pressure: 56.928Pa
- Refractive Index: N/A
- Storage Temp.: Inert atmosphere,Room Temperature
- Solubility: N/A
- Water Solubility: 54g/L at 24℃
- Merck: 14,7464
- CAS DataBase Reference: PIPERAZINE CITRATE(CAS DataBase Reference)
- NIST Chemistry Reference: PIPERAZINE CITRATE(144-29-6)
- EPA Substance Registry System: PIPERAZINE CITRATE(144-29-6)
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Safety Data
- Hazard Codes: Xi
- Statements: 36/37/38
- Safety Statements: 26
- WGK Germany: 1
- RTECS: TL3485000
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 144-29-6(Hazardous Substances Data)
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144-29-6 Usage
Uses
Used in Pharmaceutical Industry:PIPERAZINE CITRATE is used as an anthelmintic agent for the treatment of parasitic infections. It works by paralyzing parasites, allowing the host body to easily remove or expel the invading organism.
Used in Medical Applications:
PIPERAZINE CITRATE is used for the reduction of blood pressure, providing a therapeutic option for patients with hypertension.
Brand Names:
Antepar (GlaxoSmithKline)
Bryrel (Sanofi Aventis)
Indications
Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.Flammability and Explosibility
NotclassifiedMechanism of action
Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.Pharmacokinetics
Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Check Digit Verification of cas no
The CAS Registry Mumber 144-29-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 4 respectively; the second part has 2 digits, 2 and 9 respectively.Calculate Digit Verification of CAS Registry Number 144-29:
(5*1)+(4*4)+(3*4)+(2*2)+(1*9)=46
46 % 10 = 6
So 144-29-6 is a valid CAS Registry Number.
InChI:InChI=1S/2C6H8O7.3C4H10N2/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;3*1-2-6-4-3-5-1/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);3*5-6H,1-4H2
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PIPERAZINE CITRATE
