1440-12-6

Basic information

• Product Name: N-{5-[2-(5-nitrofuran-2-yl)ethenyl]-1,3,4-thiadiazol-2-yl}acetamide
• CAS NO: 1440-12-6
• Molecular Formula: C₁₀H₈N₄O₄S
• Molecular Weight: 280.2599
• Mol File: 1440-12-6.mol
• Article Data: 1

Chemical Properties

• Density: 1.589g/cm³
• Refractive Index: 1.743
• CAS DataBase Reference: N-{5-[2-(5-nitrofuran-2-yl)ethenyl]-1,3,4-thiadiazol-2-yl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{5-[2-(5-nitrofuran-2-yl)ethenyl]-1,3,4-thiadiazol-2-yl}acetamide(1440-12-6)
• EPA Substance Registry System: N-{5-[2-(5-nitrofuran-2-yl)ethenyl]-1,3,4-thiadiazol-2-yl}acetamide(1440-12-6)

Safety Data

• Hazardous Substances Data: 1440-12-6(Hazardous Substances Data)

Upstream product

• 108-33-8 5-methyl-1,3,4-thiadiazol-2-amine 
• 698-63-5 5-nitrofurane-2-carboxaldehyde 
• 108-24-7 acetic anhydride 

Downstream Products

• 1020-76-4 2-Amino-5-<2-(5-nitro-2-furyl)-vinyl>-1,3,4-thiadiazol 

Relevant articles and documents

Chemotherapeutic nitroheterocycles. Antischistosomal properties of nitrofurylvinyl and nitrothienylvinyl heterocycles

A series of 24 analogs of the experimental antischistosomal agent, 5 amino 3 [2 (5 nitro 2 furyl) vinyl] 1,2,4 oxadiazole, was prepared and evaluated in mice infected with Schistosoma mansoni. Although antischistosomal activity was widespread in the series, only four of the compounds showed significant curative properties. Compounds containing 2 imidazolyl and 2 pyridyl groups gave cure rates around 25% at 400 and 250 mg/kg dose levels, respectively. The 2 thiazolyl and 2 pyrimidyl derivatives were especially notable, yielding 100% cures at 250 and 200 mg/kg dose levels, respectively.