1440008-97-8Relevant academic research and scientific papers
Highly enantioselective [4+2] annulation via organocatalytic Mannich-reductive cyclization: One-pot synthesis of functionalized piperidines
Kumar, Indresh,Ramaraju, Panduga,Mir, Nisar A.,Singh, Deepika,Gupta, Vivek K.,Rajnikant
, p. 5645 - 5647 (2013)
A new method for one-pot synthesis of 2,3-substituted piperidine from N-PMP aldimine and aqueous glutaraldehyde via formal [4+2] cycloaddition is reported. This reaction involves organocatalytic direct Mannich reaction-reductive cyclization with high yields (up to 90%) and excellent enantioselectivities (up to >99%). The practicability of this method is also shown at a gram scale as well as through the synthesis of functionalized (-)-anabasine.
