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144010-02-6

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144010-02-6 Usage

General Description

3-Piperazinobenzisothiazole hydrochloride is a chemical compound that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a hydrochloride salt of 3-Piperazinobenzisothiazole, which is a benzothiazole derivative. 3-Piperazinobenzisothiazole hydrochloride has the potential to act as a potent and selective antitumor agent due to its ability to inhibit the growth of various cancer cell lines. It is also used in the synthesis of other heterocyclic compounds and is being studied for its potential use in the treatment of neurodegenerative diseases. Additionally, 3-Piperazinobenzisothiazole hydrochloride has been investigated for its antimicrobial and antifungal properties, showing promise as a potential agent against various pathogens.

Check Digit Verification of cas no

The CAS Registry Mumber 144010-02-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,0,1 and 0 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 144010-02:
(8*1)+(7*4)+(6*4)+(5*0)+(4*1)+(3*0)+(2*0)+(1*2)=66
66 % 10 = 6
So 144010-02-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H13N3S.ClH/c1-2-4-10-9(3-1)11(13-15-10)14-7-5-12-6-8-14;/h1-4,12H,5-8H2;1H

144010-02-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Piperazinobenzisothiazole Hydrochloride

1.2 Other means of identification

Product number -
Other names 3-Piperazinobenzisothiazole hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:144010-02-6 SDS

144010-02-6Relevant articles and documents

A key intermediate for the preparation of ziprasidone

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Paragraph 0119-0120, (2018/04/03)

The present invention relates to a ziprasidone key intermediate preparation method, wherein benzo[d]isothiazole-3-ol (or one) is adopted as a raw material, and reacts with a substituted sulfonyl chloride or anhydride under an alkaline condition to obtain benzo[d]isothiazole-3-substituted sulfonate, and the benzo[d]isothiazole-3-substituted sulfonate reacts with piperazine to prepare the ziprasidone key intermediate 3-(1-piperazinyl)-1,2-benzoisothiazole. The method of the present invention has characteristics of simple operation, easily available raw materials, less byproducts, simple post-treatment, less industrial three-waste and the like, and is especially suitable for industrial production.

New disulfide route to 3-(1-piperazinyl)-1,2-benzisothiazole. Nucleus for atypical antipsychotic drugs

Walinsky, Stanley W.,Fox, Darrell E.,Lambert, John F.,Sinay, Terry G.

, p. 126 - 130 (2013/09/08)

A new, one-step commercial process for the preparation of 3-(1-piperazinyl)-l,2-benzisothiazole hydrochloride, a key intermediate for the syntheses of some new, "atypical antipsychotic" drugs, was developed. Reaction of bis(2-cyanophenyl) disulfide with excess piperazine at 120-140 °C for 3-24 h in the presence of small amounts of DMSO and 2-propanol formed 3-(l-piperazinyl)-l,2-benzisothiazole in 75-80% yields. The DMSO oxidized the liberated 2-mercaptobenzonitrile to regenerate bis(2-cyanophenyl) disulfide, thereby enabling the utilization of both halves of the symmetrical disulfide to generate product. The reaction mechanism for the conversion of the bis(2-cyanophenyl) disulfide to 3-amino-1,2-benzisothiazole involves the formation of ring-opened sulfenamide and benzamidine intermediates and then their subsequent ring closure to regenerate the 1,2-benzisothiazole nucleus. A safe, efficient, and robust process to prepare 3-(l-piperazinyl)-1,2-benzisothiazole under very concentrated reaction conditions was developed and successfully scaled up in the pilot plant to support the development of ziprasidone.

Pro-drugs of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one

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, (2008/06/13)

The present invention relates to a pro-drug of ziprasidone or pharmaceutically acceptable salts thereof, processes for its preparation, and pharmaceutical compositions and methods of treatment comprising said pro-drug.

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