144016-26-2

Upstream product

• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 212912-47-5 2RS,4S,5R-4-Methyl-3-p-methylphenylsulphonyl-2-methoxy-5-phenyl-1,3-oxazolidine 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 144016-22-8 (2S,4R,5R)-2-methoxy-4-methyl-3-(4-methylbenzenesulfonyl)-5-phenyl-1,3-oxazolidine 

Relevant academic research and scientific papers

Norpseudoephedrine-derived 2-methoxy-2-sulfonyl-1,3-oxazolidines: Chiral, highly diastereoselective formyl cation equivalents

(2S,4R,5R)-2-Methoxy-4-methyl-3-(4-methylbenzenesulfonyl)-5- phenyl-1,3-oxazolidine (2c) adds trimethylsilyl 1-cycloalkenyl ethers under Lewis acid catalysis with complete induced and high simple diastereoselectivity to yield homichiral oxazolidine-masked

Electrophilic α-formylation of carbonyl compounds using norephedrine-derived 2-metohoxy oxazolidines. A novel asymmetric formation of quaternary stereocenters

The BF3·Et2O promoted addition of enamines and silylenolethers, to the nor-ephedrine-derived orthoamides 1 or 5 has been studied. A judicious choice of the type of nucleophile and electrophile leads to useful selectivities. When a quaternary α-carbonyl stereocenter is created, the direct removal of the chiral auxiliary is possible and renders the overall process an efficient asymmetric carbonyl α-formylation.