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144026-74-4

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144026-74-4 Usage

Uses

3-(3-Methoxyphenyl)-1H-pyrazole is used as pharmaceutical intermediates.

Check Digit Verification of cas no

The CAS Registry Mumber 144026-74-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,0,2 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 144026-74:
(8*1)+(7*4)+(6*4)+(5*0)+(4*2)+(3*6)+(2*7)+(1*4)=104
104 % 10 = 4
So 144026-74-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2O/c1-13-9-4-2-3-8(7-9)10-5-6-11-12-10/h2-7H,1H3,(H,11,12)

144026-74-4 Well-known Company Product Price

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  • Alfa Aesar

  • (H50435)  3-(3-Methoxyphenyl)-1H-pyrazole, 97%   

  • 144026-74-4

  • 1g

  • 977.0CNY

  • Detail
  • Alfa Aesar

  • (H50435)  3-(3-Methoxyphenyl)-1H-pyrazole, 97%   

  • 144026-74-4

  • 5g

  • 4639.0CNY

  • Detail

144026-74-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(3-methoxyphenyl)-1H-pyrazole

1.2 Other means of identification

Product number -
Other names 3-methoxy-1-pyrazol-3-ylbenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:144026-74-4 SDS

144026-74-4Downstream Products

144026-74-4Relevant articles and documents

Optimization of ether and aniline based inhibitors of lactate dehydrogenase

Christov, Plamen P.,Kim, Kwangho,Jana, Somnath,Romaine, Ian M.,Rai, Ganesha,Mott, Bryan T.,Allweil, Alexander A.,Lamers, Alexander,Brimacombe, Kyle R.,Urban, Daniel J.,Lee, Tobie D.,Hu, Xin,Lukacs, Christine M.,Davies, Douglas R.,Jadhav, Ajit,Hall, Matthew D.,Green, Neal,Moore, William J.,Stott, Gordon M.,Flint, Andrew J.,Maloney, David J.,Sulikowski, Gary A.,Waterson, Alex G.

, (2021/04/12)

Lactate dehydrogenase (LDH) is a critical enzyme in the glycolytic metabolism pathway that is used by many tumor cells. Inhibitors of LDH may be expected to inhibit the metabolic processes in cancer cells and thus selectively delay or inhibit growth in transformed versus normal cells. We have previously disclosed a pyrazole-based series of potent LDH inhibitors with long residence times on the enzyme. Here, we report the elaboration of a new subseries of LDH inhibitors based on those leads. These new compounds potently inhibit both LDHA and LDHB enzymes, and inhibit lactate production in cancer cell lines.

SMALL MOLECULE INHIBITORS OF LACTATE DEHYDROGENASE AND METHODS OF USE THEREOF

-

, (2016/07/27)

Provided is a compound of formula (I)[Formula (I) should be inserted here], in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/ or lactate dehydrogenase B (LDHB) activity in a cell.

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