144036-24-8

Upstream product

• 154083-41-7 3-((tert-butyldimethylsilyl)oxy)-4-methoxybenzoic acid 
• 913985-11-2 3-(tert-butyl-dimethyl-silanyloxy)-N-(3,5-dichloro-pyridin-4-yl)-4-methoxy-benzamide 
• 159782-90-8 N-(3,5-dichloropyrid-4-yl)-3-benzoyloxy-4-methoxybenzamide 
• 584-08-7 potassium carbonate 
• 22002-44-4 2-chloro-1-methoxy-4-methylbenzene 
• 252332-32-4 N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-pivaloyloxybenzamide 

Downstream Products

• 252332-15-3 N-(3,5-Dichloropyridin-4-yl)-3-(4-hydroxytetrahydrofuran-3-yloxy)-4-methoxybenzamide 
• 913985-12-3 (3,5-dichloro-pyridin-4-yl)-(3-hydroxy-4-methoxy-benzoyl)-carbamic acid tert-butyl ester 
• 162401-32-3 roflumilast 
• 159782-26-0 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(methoxy)benzamide 

Relevant academic research and scientific papers

Preparation methods of anti-inflammatory agent roflumilast for inhibiting PDE4 enzymatic activity and intermediate of roflumilast

The invention discloses preparation methods of an anti-inflammatory agent roflumilast for inhibiting the PDE4 enzymatic activity and an intermediate of the roflumilast. A chemical name of the anti-inflammatory agent roflumilast for inhibiting the PDE4 enzymatic activity is 3-(cyclopropyl methoxy)-N-(3,3-dichloropyridine-4-yl)-4-(difluoromethoxy) benzamide, the chemical formula of the roflumilast is C17H14C12F2N2O3, and the structural formula of the roflumilast is described as follow: (the structural formula is shown in the description). The preparation methods are concise in preparation technological process, available in raw material, simple in synthetic condition and high in yield and purity of a product, is environmentally friendly, is beneficial to realizing industrialization, lowers the production cost and is suitable for mass production; and the searched novel preparation methods of the roflumilast and the intermediate thereof have great significance on economical technology of the roflumilast.

AZOLE-BASED PHOSPHODIESTERASE INHIBITORS

The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds of Formula (I), pharmaceutical compositions containing the compounds described herein and their use as PDE type IV selective inhibitors are provided.

Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors

Compounds of the formula I in which R1, R2, R3, R4, R5, m and n have the meanings cited in the description, are novel effective PDE-inhibitors.

COMPOUNDS CONTAINING PHENYL LINKED TO ARYL OR HETEROARYL BY AN ALIPHATIC- OR HETEROATOM-CONTAINING LINKING GROUP

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase

Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.