1440432-76-7

Upstream product

• 2622-05-1 allylmagnesium bromide 
• 75677-02-0 3-(4-chlorophenyl)propionaldehyde 

Downstream Products

• 1440432-05-2 (2S,4R,6S)-2-(4''-methoxyphenethyl)-6-(3'''-bromo-4'''-hydroxy-5'''-methoxyphenyl)tetrahydropyran-4-yl-3''''-(4'''''-methoxyphenyl)propyl carbonate 
• 1440432-04-1 (2S,4R,6S)-2-(4''-chlorophenethyl)-6-(3''',4'''-dihydroxyphenyl)tetrahydropyran-4-yl-3''''-(4'''''-methoxyphenyl)propyl carbonate 
• 1440431-37-7 (2S,4R,6S)-2-(4''-chlorophenethyl)-6-(4'''-hydroxy-3'''-methoxyphenyl)tetrahydropyran-4-ol 
• 1440431-92-4 (2S,4R,6S)-2-(4''-chlorophenethyl)-6-(4'''-hydroxyphenyl)tetrahydropyran-4-yl-3''''-(4'''''-methoxyphenyl)-propyl carbonate 

Relevant academic research and scientific papers

A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin

A Prins cyclization between a polymerbound aldehyde and a homoallylic alcohol served as the key step in the synthesis of tetrahydropyran derivatives. A phenotypic screen led to the identification of compounds that inhibit mitosis (as seen by the accumulation of round cells with condensed DNA and membrane blebs; see picture). These compounds were termed tubulexins as they target the CSE1L protein and the vinca alkaloid binding site of tubulin.