1440515-06-9

Upstream product

• 2637-34-5 2-Sulfanylpyridine 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 66715-65-9 pyridine-2-sulfonyl chloride 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 141410-06-2 (S)-indoline-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

NaClO2-mediated preparation of pyridine-2-sulfonyl chlorides and synthesis of chiral sulfonamides

A simple method to prepare azaarenesulfonyl chlorides by NaClO2-mediated oxidative chlorination of azaarenethiols have been developed, with water as the solvent. Easy purification by simple extraction and concentration gives the products in good yields. The azaarenesulfonyl chlorides readily undergo condensation with chiral amines to afford chiral sulfonamides.

Synthesis of indolines via Pd(II)-catalyzed amination of C-H bonds using PhI(OAc)2 as the bystanding oxidant

The Pd(II)-catalyzed intramolecular C-H amination of 2-pyridinesulfonyl- protected phenethylamine derivatives has been achieved using PhI(OAc) 2 as a bystanding oxidant, providing access to a variety of substituted indoline derivatives in good yields. The use of the 2-pyridinesulfonyl protecting group allows for facile deprotection following C-H functionalization.