1440523-77-2Relevant academic research and scientific papers
One-Pot Synthesis of Cyclic Isothioureas
Wang, Jun,Sun, Zhihua
, p. 1751 - 1756 (2021/08/27)
The one-pot synthesis of cyclic isothioureas is reported. This method provides a straightforward and efficient approach to the synthesis of a broad range of cyclic isothioureas with yields of up to 90% and in quantities of up to 5 g. It is of great value for the preparation of classic organocatalysts, such as benzotetramisole and homobenzotetramisole.
Concise synthesis of the isothiourea organocatalysts homobenzotetramisole and derivatives
Ranieri, Beatrice,Robles, Omar,Romo, Daniel
, p. 6291 - 6296 (2013/07/25)
A concise approach to the synthesis of homobenzotetramisole and derivatives is described. Our strategy features a one-pot acylation-cyclization of 2-aminobenzothiazole with α,β-unsaturated acid chlorides to afford annulated pyrimidones. Subsequent Grignard addition followed by acid-promoted dehydration and reduction provides good overall yields of the title compounds in three steps and in quantities up to 10 g. The synthesis employs low-cost and readily available starting materials and enables access to both optical antipodes of these increasingly useful nucleophilic catalysts following chiral separation.
