144060-96-8

Basic information

• Product Name: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate
• Synonyms: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate;Ethy1,2-(3-bromo-4-isobutoxyphenyl)-4-methyl-5-thiazolecarbokylate;2-[3-broMo-4-(2-Methylpropoxy)phenyl]-5-carboxylato-1-ethyl-4-Methyl-1H-1$l^{4},3-thiazol-1-yl;ethyl 2-(3-broMo-4-isobutoxyphenyl)-4-Methylthiazole-5-carboxylate;2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
• CAS NO: 144060-96-8
• Molecular Formula: C₁₇H₂₀BrNO₃S
• Molecular Weight: 398.319
• EINECS: 1533716-785-6
• Mol File: 144060-96-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 476.5 °C at 760 mmHg
• Flash Point: 242 °C
• Appearance: /
• Density: 1.335 g/cm³
• Vapor Pressure: 3.02E-09mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate(144060-96-8)
• EPA Substance Registry System: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate(144060-96-8)

Safety Data

• Hazardous Substances Data: 144060-96-8(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate is a chemical compound with the molecular formula C18H20BrNO3S. It is a thiazole derivative with a bromo substitution and an isobutoxyphenyl group attached to the 2-position of the thiazole ring. Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and potential biological activities. The presence of the thiazole moiety in its structure also suggests possible antimicrobial and antifungal properties, making it a valuable compound in drug discovery and development. Additionally, the ethyl ester functional group at the 5-position of the thiazole ring can contribute to the compound's pharmacokinetic properties and bioavailability when used in medicinal formulations.

InChI:InChI=1/C17H20BrNO3S/c1-5-21-17(20)15-11(4)19-16(23-15)12-6-7-14(13(18)8-12)22-9-10(2)3/h6-8,10H,5,9H2,1-4H3

Upstream product

• 25984-64-9 3-bromo-4-hydroxy-thiobenzamide 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 2315-86-8 3-bromo-4-hydroxybenzonitrile 
• 144060-79-7 2-(3-bromo-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester 
• 78-77-3 Isobutyl bromide 
• 208665-96-7 3-bromo-4-isobutoxyphenylthiocarboxamide 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 160844-75-7 2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester 
• 1364398-15-1 ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride 
• 144060-85-5 ethyl 2-(4-isobutyloxy-3-trifluoromethylphenyl)-4-methyl-5-thiazolecarboxylate 

Relevant articles and documents

PROCESS TO PREPARE ETHYL 4-METHYL-2-(4-(2-METHYLPROPYLOXY)-3-CYANOPHENYL)-5-THIAZOLECARBOXYLATE

Disclosed is a process for the preparation of Ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate (I) the key intermediate for the preparation of [2-[3-cyano-4-(2-Methyl-propoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (Febuxostat, I(A)) is approved under the trademark Uloric? by the US Food and Drug Administration for the treatment of hyperuricemia and gouty arthritis.

A PROCESS FOR THE PREPARATION OF FEBUXOSTAT

The present invention relates to a process for the preparation of Febuxostat, useful in the pharmaceutical field for the treatment of the hyperuricemia.