144060-99-1

Basic information

• Product Name: 2-(4-Fluorophenyl)-4-methyl-5-thiazolecarboxylicacid
• Synonyms: 2-(4-Fluorophenyl)-4-methyl-5-thiazolecarboxylicacid;2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid;5-Thiazolecarboxylic acid, 2-(4-fluorophenyl)-4-methyl-
• CAS NO: 144060-99-1
• Molecular Formula: C₁₁H₈FNO₂S
• Molecular Weight: 237.2501232
• Mol File: 144060-99-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 417°C at 760 mmHg
• Flash Point: 206°C
• Appearance: /
• Density: 1.392g/cm³
• Vapor Pressure: 1.07E-07mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-Fluorophenyl)-4-methyl-5-thiazolecarboxylicacid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Fluorophenyl)-4-methyl-5-thiazolecarboxylicacid(144060-99-1)
• EPA Substance Registry System: 2-(4-Fluorophenyl)-4-methyl-5-thiazolecarboxylicacid(144060-99-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 144060-99-1(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorophenyl)-4-methyl-5-thiazolecarboxylic acid is a chemical compound with the molecular formula C12H9FN2O2S. It is a thiazolecarboxylic acid derivative with a fluorophenyl and methyl group attached to the thiazole ring. 2-(4-Fluorophenyl)-4-methyl-5-thiazolecarboxylicacid has potential pharmacological and therapeutic properties and may be used in the development of pharmaceutical drugs. Its structure suggests that it may have anti-inflammatory, antimicrobial, or other biological activities. Further research and studies are needed to fully understand the potential applications and properties of this chemical compound.

InChI:InChI=1/C11H8FNO2S/c1-6-9(11(14)15)16-10(13-6)7-2-4-8(12)5-3-7/h2-5H,1H3,(H,14,15)

Upstream product

• 22179-72-2 4-fluorothiobenzamide 
• 317319-17-8 4-methyl-2-(4-fluorophenyl)thiazole-5-carboxylic acid ethyl ester 

Downstream Products

• 1354948-46-1 C₂₃H₂₂FN₃O₃S 
• 343322-22-5 2-methyl-2-[4-{[(4-methyl-2-[4-fluorophenyl]-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester 

Relevant articles and documents

Microwave Assisted Synthesis and Antibacterial Activity of New 1,3,4-Thiadiazoles and 1,2,4-Triazoles Derived from 2-{2-[2-(4-Fluorophenyl)-4-methylthiazol-5-yl]-1H-benzo[d]imidazol-1-yl}acetohydrazide

Abstract: A series of novel derivatives of1-(2-{2-[2-(4-fluorophenyl)-4-methylthiazol-5-yl]-1H-benzo[d]imidazol-1-yl}acetyl)-4-phenylthiosemicarbazide,5-({2-[2-(4-fluorophenyl)-4-methylthiazol-5-yl]-1H-benzo[d]imidazol-1-yl}methyl)-4-phenyl-4H-1,2,4-triaz

Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents

The peroxisome proliferator activated receptors PPARα, PPARγ, and PPARδ are ligand-activated transcription factors that play a key role in lipid homeostasis. The fibrates raise circulating levels of high-density lipoprotein cholesterol and lower levels of triglycerides in part through their activity as PPARα agonists; however, the low potency and restricted selectivity of the fibrates may limit their efficacy, and it would be desirable to develop more potent and selective PPARα agonists. Modification of the selective PPARδ agonist 1 (GW501516) so as to incorporate the 2-aryl-2-methylpropionic acid group of the fibrates led to a marked shift in potency and selectivity toward PPARα agonism. Optimization of the series gave 25a, which shows EC50 = 4 nM on PPARα and at least 500-fold selectivity versus PPARγ and PPARγ. Compound 25a (GW590735) has been progressed to clinical trials for the treatment of diseases of lipid imbalance.