144061-16-5

Basic information

• Product Name: 2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID
• Synonyms: CHEMBRDG-BB 4013405;2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID;2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxylic acid(SALTDATA: 1.3H2O)
• CAS NO: 144061-16-5
• Molecular Formula: C₁₁H₆F₃NO₂S
• Molecular Weight: 273.23
• Mol File: 144061-16-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 186 °C
• Boiling Point: 405.2 °C at 760 mmHg
• Flash Point: 198.9 °C
• Appearance: /
• Density: 1.489 g/cm³
• Vapor Pressure: 2.71E-07mmHg at 25°C
• Refractive Index: 1.558
• PKA: 3.33±0.10(Predicted)
• CAS DataBase Reference: 2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID(144061-16-5)
• EPA Substance Registry System: 2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID(144061-16-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 144061-16-5(Hazardous Substances Data)

Usage

General Description

2-(4-trifluoromethyl-phenyl)-thiazole-4-carboxylic acid is a chemical compound consisting of a thiazole ring with a carboxylic acid group and a phenyl ring substituted with a trifluoromethyl group at the 4-position. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals, due to its potential biological activities. 2-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID has been investigated for its potential use in the treatment of various diseases and conditions. It is important to handle this compound with care and follow safety guidelines, as it is a potentially hazardous substance.

InChI:InChI=1/C11H6F3NO2S/c12-11(13,14)7-3-1-6(2-4-7)9-15-8(5-18-9)10(16)17/h1-5H,(H,16,17)

Upstream product

• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 175204-88-3 2-[4-(trifluoromethyl)phenyl]thiazole-4-carboxylic acid ethyl ester 
• 70-23-5 ethyl Bromopyruvate 
• 72505-21-6 4-trifluoromethylbenzthioamide 

Downstream Products

• 857284-28-7 C₁₁H₅ClF₃NOS 

Relevant articles and documents

Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor

Fibroblast activation protein (FAP) belongs to the family of prolyl-specific serine proteases and displays both exopeptidase and endopeptidase activities. FAP expression is undetectable in most normal adult tissues, but is greatly upregulated in sites of tissue remodeling, which include fibrosis, inflammation and cancer. Due to its restricted expression pattern and dual enzymatic activities, FAP inhibition is investigated as a therapeutic option for several diseases. In the present study, we described the structure–activity relationship of several synthesized compounds against DPPIV and prolyl oligopeptidase (PREP). In particular, BR102910 (compound 24) showed nanomolar potency and high selectivity. Moreover, the in vivo FAP inhibition study of BR102910 (compound 24) using C57BL/6J mice demonstrated exceptional profiles and satisfactory FAP inhibition efficacy. Based on excellent in vitro and in vivo profiles, the potential of BR102910 (compound 24) as a lead candidate for the treatment of type 2 diabetes is considered.