1440650-34-9

Basic information

• Product Name: N-(4-(dimethylamino)benzyl)-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxamide
• Synonyms: N-(4-(dimethylamino)benzyl)-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxamide
• CAS NO: 1440650-34-9
• Molecular Weight: 322.41
• Mol File: 1440650-34-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-(dimethylamino)benzyl)-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(dimethylamino)benzyl)-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxamide(1440650-34-9)
• EPA Substance Registry System: N-(4-(dimethylamino)benzyl)-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxamide(1440650-34-9)

Safety Data

• Hazardous Substances Data: 1440650-34-9(Hazardous Substances Data)

Upstream product

• 81438-51-9 ethyl 2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate 
• 10003-74-4 4-(dimethylamino)benzylamine dihydrochloride salt 
• 81438-52-0 2,6-dimethylimidazo[1,2-a]pyrimidine-3-carboxylic acid 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 

Relevant articles and documents

Advancement of imidazo[1,2-a]pyridines with improved pharmacokinetics and nM activity vs. Mycobacterium tuberculosis

A set of 14 imidazo[1,2-a]pyridine-3-carboxamides was synthesized and screened against Mycobacterium tuberculosis H37Rv. The minimum inhibitory concentrations of 12 of these agents were ≤1 μM against replicating bacteria and 5 compounds (9, 12, 16, 17, and 18) had MIC values ≤0.006 μM. Compounds 13 and 18 were screened against a panel of MDR and XDR drug resistant clinical Mtb strains with the potency of 18 surpassing that of clinical candidate PA-824 by nearly 10-fold. The in vivo pharmacokinetics of compounds 13 and 18 were evaluated in male mice by oral (PO) and intravenous (IV) routes. These results indicate that readily synthesized imidazo[1,2-a]pyridine-3-carboxamides are an exciting new class of potent, selective anti-TB agents that merit additional development opportunities.