144066-84-2

Upstream product

• 144066-82-0 Acetic acid 2-isopropenyl-3-methyl-but-2-enyl ester 
• 144066-83-1 Acetic acid 5-chloro-5-cyano-2,6,6-trimethyl-cyclohex-1-enylmethyl ester 
• 199177-35-0 3-Methoxymethoxymethyl-2,2,4-trimethyl-7-oxa-bicyclo[4.1.0]hept-3-ene 
• 199177-30-5 2-Methoxymethoxymethyl-1,3,3-trimethyl-cyclohexa-1,4-diene 
• 199177-31-6 (2,2,4-Trimethyl-7-oxa-bicyclo[4.1.0]hept-3-en-3-yl)-methanol 
• 199177-32-7 (+/-)-2-hydroxy-β-cyclogeraniol 
• 162376-82-1 2,6,6-Trimethyl-1,4-cyclohexadiene-1-carboxaldehyde 
• 199177-36-1 Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester 
• 108-24-7 acetic anhydride 
• 152328-14-8 3-Hydroxymethyl-2,2,4-trimethyl-cyclohex-3-enone 

Downstream Products

• 144066-88-6 Acetic acid (S)-3-hydroxy-2,6,6-trimethyl-5-oxo-cyclohex-1-enylmethyl ester 
• 144066-89-7 Acetic acid (S)-3-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-5-oxo-cyclohex-1-enylmethyl ester 

Relevant academic research and scientific papers

Taxol synthesis: Synthesis of A-ring and a methodology for substituted cyclohexadienes

A fully functionalised synthesis of taxol A-ring, through Michael/Wittig reaction and regioselective opening epoxide as key steps and also a methodology for substituted cyclohexadienes through tandem Michael/Wittig reaction is described.

A Convergent Strategy Towards Taxol. A Facile Enantioselective Entry Into a Fully Functionalized Ring A System

Key intermediates 10-12 related to the taxol ring A system have been synthesized in enantiomerically pure form by a short and efficient route featuring a Diels-Alder reaction and a Corey oxazaborolidine reduction.