144072-16-2 Usage
Uses
Used in Pharmaceutical Research:
[1,1-Bicyclopropyl]-2-carboxylicacid,ethylester,cis-(9CI) is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows for the creation of novel drug candidates with potential applications in treating various medical conditions.
Used in Chemical Research:
In the field of chemical research, [1,1-Bicyclopropyl]-2-carboxylicacid,ethylester,cis-(9CI) is utilized as a building block for the development of new materials and chemical products. Its distinctive properties contribute to the advancement of various chemical applications, including the creation of new polymers and other advanced materials.
Used in Drug Synthesis:
[1,1-Bicyclopropyl]-2-carboxylicacid,ethylester,cis-(9CI) is employed as a crucial component in the synthesis of new drugs. Its unique structure enables the development of innovative pharmaceuticals with improved efficacy and reduced side effects, ultimately benefiting patients and the healthcare industry.
Used in Material Science:
In material science, [1,1-Bicyclopropyl]-2-carboxylicacid,ethylester,cis-(9CI) is used as a building block for the development of new materials with enhanced properties. Its incorporation into various materials can lead to improved performance, durability, and functionality, making it a valuable asset in the field of material science and engineering.
Check Digit Verification of cas no
The CAS Registry Mumber 144072-16-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,0,7 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 144072-16:
(8*1)+(7*4)+(6*4)+(5*0)+(4*7)+(3*2)+(2*1)+(1*6)=102
102 % 10 = 2
So 144072-16-2 is a valid CAS Registry Number.
144072-16-2Relevant academic research and scientific papers
Rassadin, Valentin A.,Sokolov, Viktor V.,Khlebnikov, Alexander F.,Ulin, Nikolay V.,Kozhushkov, Sergei I.,De Meijere, Armin
, p. 372 - 376 (2012)
Ethenylcyclopropane (5) was prepared from cyclopropyl methyl ketone (1) in four simple, easily scalable steps (bromination, reduction to the bromohydrin, acetylation of the latter, and reductive elimination with Zn/Cu) in an overall yield of 56%. 1-Bromo-2-cyclopropylcyclopropane (7) (approximately 1:1 mixture of cis- and trans-7) was prepared from 5 via the dibromide 6, and from 7 the boronate cis/trans-8 (ratio 1:1) was obtained in 96% yield. Rhodium(II)- catalyzed cyclopropanation of 5 with ethyl diazoacetate gave ethyl 2-cyclopropylcyclopropanecarboxylate (cis/trans-9, ratio 1:1.4) in 80% yield. The latter was also prepared in 79% overall yield by sequential cyclopropanation of buta-1,3-diene with ethyl diazoacetate [under RhOAc)catalysis] and diiodomethane/diethylzinc/trifluoroacetic acid. Curtius degradation of 2-cyclopropylcyclopropanecarboxylic acid (obtained by hydrolysis of the ester) gave 2-cyclopropylcyclopropanamine (1:1.2 mixture of cis- and trans-isomers) in 58% yield. Georg Thieme Verlag Stuttgart New York.
