144072-99-1Relevant academic research and scientific papers
Mag: A Cα-methylated, side-chain unsaturated α-amino acid. Introduction into model peptides and conformational preference
Peggion, Cristina,Flammengo, Roberto,Mossel, Eric,Broxterman, Quirinus B.,Kaptein, Bernard,Kamphuis, Johan,Formaggio, Fernando,Crisma, Marco,Toniolo, Claudio
, p. 3589 - 3601 (2000)
By a chemo-enzymatic approach we synthesized the chiral, C(α)- methylated α-amino acid Mag, characterized by a side-chain C(γ)=C(δ) bond. We also prepared a series of model peptides containing Mag in combination with Aib and Ala. All of the peptides were fully characterized and their conformational preference was determined in solution by FT-IR absorption and 1H NMR investigations. X-Ray diffraction analyses of L-Mag, a derivative and three peptides are also presented. We find that this C(α)-methylated α- amino acid is an excellent β-turn and 310-helix former. A peptide with two Mag residues one on top of the other after one complete turn of the 310- helix has been synthesized and characterized. 2000 Elsevier Science Ltd.
