1440753-99-0Relevant academic research and scientific papers
2-catalyzed directed N -Boc amidation of arenes "on water"
Ali, Md Ashif,Yao, Xiayin,Sun, Hao,Lu, Hongjian
, p. 1513 - 1516 (2015/03/30)
Rhodium(III) catalysis "on water" is effective for directed C-H amidation of arenes. The catalytic process is promoted by OH groups present on the hydrophobic water surface and is inefficient in all (most) common organic solvents investigated so far. In the presence of easily prepared tert-butyl 2,4-dinitrophenoxycarbamate, a new and stable nitrene source, the "on water" reaction can efficiently provide the desired N-Boc-aminated products with good functional group tolerance.
Cobalt(III)-catalyzed C-H amidation of arenes using acetoxycarbamates as convenient amino sources under mild conditions
Patel, Pitambar,Chang, Sukbok
, p. 853 - 858 (2015/02/19)
The Co(III)-catalyzed direct C-H amidation of arenes has been developed using O-acylcarbamates as a convenient amino source. This reaction proceeded in high efficiency under external oxidant-free conditions with a broad range of arene substrates, includin
N -substituted hydroxylamines as synthetically versatile amino sources in the iridium-catalyzed mild C-H amidation reaction
Patel, Pitambar,Chang, Sukbok
supporting information, p. 3328 - 3331 (2014/07/08)
N-Substituted hydroxylamines such as aroyloxy- or acyloxycarbamates were successfully employed as synthetically versatile amino precursors in the iridium-catalyzed direct C-H amidation of arenes. The reaction proceeds smoothly at room temperature over a broad range of substrates with high functional group tolerance to afford N-substituted arylamine products.
Rh[III]-catalyzed C-H amidation using aroyloxycarbamates to give N-Boc protected arylamines
Grohmann, Christoph,Wang, Honggen,Glorius, Frank
, p. 3014 - 3017 (2013/07/26)
The Rh(III)-catalyzed amidation of C(sp2)-H bonds by the use of electron-deficient aroyloxycarbamates as efficient electrophilic amidation partners is reported. The reaction proceeded under mild conditions with broad functional group tolerance, and pyridine and O-methyl hydroxamic acids serve as efficient directing groups, giving access to valuable N-Boc protected arylamines (also Fmoc and Cbz). Preliminary mechanistic experiments are discussed.
