1440954-94-8

Basic information

• Product Name: tert-butyl 2-amino-4,5,7,8-tetrahydrothiazolo[5,4-d]azepine-6-carboxylate
• Synonyms: tert-butyl 2-amino-4,5,7,8-tetrahydrothiazolo[5,4-d]azepine-6-carboxylate;tert-butyl 2-amino-7,8-dihydro-4H-thiazolo[4,5-d]azepine-6(5H)-carboxylate
• CAS NO: 1440954-94-8
• Molecular Formula: C12H19N3O2S
• Molecular Weight: 269.37
• Mol File: 1440954-94-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 2-amino-4,5,7,8-tetrahydrothiazolo[5,4-d]azepine-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-amino-4,5,7,8-tetrahydrothiazolo[5,4-d]azepine-6-carboxylate(1440954-94-8)
• EPA Substance Registry System: tert-butyl 2-amino-4,5,7,8-tetrahydrothiazolo[5,4-d]azepine-6-carboxylate(1440954-94-8)

Safety Data

• Hazardous Substances Data: 1440954-94-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 86029-68-7 5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-yl-amine 

Downstream Products

• 1352925-59-7 2-bromo-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepine-6-carboxylic acid tert-butyl ester 

Relevant articles and documents

NOVEL PYRAZOLOPYRIMIDINES

This invention relates to novel pyrazolopyrimidines and their use as metabotropic glutamate 5 receptor antagonists (mGlu5 receptor antagonists), pharmaceutical compositions containing the same, and methods of using the same as agents for treatment or amelioration of mGlu5 receptor mediated disorders.

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.