1440956-77-3Relevant academic research and scientific papers
Regioselective Construction of α,α-Disubstituted Allylic Amines by the Ruthenium-Catalyzed Allylic Amination of Tertiary Allylic Acetates
Mizuno, Shota,Terasaki, Shou,Shinozawa, Toru,Kawatsura, Motoi
supporting information, p. 504 - 507 (2017/02/10)
The ruthenium-catalyzed regioselective allylic amination of tertiary allylic acetates with several types of amines has been accomplished. The reaction was effectively catalyzed by CpRuCl2/5,5′-dimethyl-2,2′-bipyridine or its related ruthenium catalyst systems, and α,α-disubstituted allylic amines were formed as a single regioisomer in moderate to high yields.
Silver-catalyzed ring-opening of cyclopropenes: Preparation of tertiary α-branched allylic amines
Phan, Diem T.H.,Dong
, p. 5726 - 5731 (2013/07/05)
Herein we report a silver-catalyzed ring-opening of cyclopropenes by addition of amines. This transformation is thought to occur via an argentocarbenium intermediate and affords tertiary α-branched allylic amines in good yields and high regioselectivity. The protocol applies to various primary and secondary amines, as well as sterically hindered cyclopropenes. Friedel-Crafts cyclization of the cationic intermediate occurs as a competitive pathway to form methyl-indene.
