1440976-05-5Relevant academic research and scientific papers
A palladium-catalyzed coupling of 3-chloroquinoxalinones with various nitrogen-containing nucleophiles
Brachet, Etienne,Peyrat, Jean-Francois,Brion, Jean-Daniel,Messaoudi, Samir,Alami, Mouad
, p. 3808 - 3816 (2014/03/21)
An efficient and general palladium-catalyzed coupling of 3-chloro-quinoxalinones with a variety of nitrogen-containing nucleophiles such as (hetero)aromatic and aliphatic amides as well as some challenging weakly nucleophilic nitrogen compounds including lactams, carbamates and NH-containing azoles is described. In all cases, the reactions take place rapidly and cleanly in dioxane using Pd(OAc)2 as a catalyst, Xantphos as a ligand and K2CO3 as a base furnishing the coupling 3-N-substituted quinoxalinone products in good to excellent yields. This journal is The Royal Society of Chemistry 2013.
