1440976-06-6Relevant academic research and scientific papers
Transition-metal free C3-amidation of quinoxalin-2(1: H)-ones using Selectfluor as a mild oxidant
Yuan, Jin-Wei,Zhu, Jun-Liang,Li, Bing,Yang, Liang-Yu,Mao, Pu,Zhang, Shou-Ren,Li, Yan-Chun,Qu, Ling-Bo
, p. 10178 - 10187 (2019/12/26)
A practical and efficient synthetic route to construct a variety of 3-amidated quinoxalin-2(1H)-ones was developed via transition-metal free direct oxidative amidation of quinoxalin-2(1H)-ones with amidates using Selectfluor reagent as a mild oxidant. This protocol features mild reaction conditions, operational simplicity, broad substrate scope, and good to excellent yields.
A palladium-catalyzed coupling of 3-chloroquinoxalinones with various nitrogen-containing nucleophiles
Brachet, Etienne,Peyrat, Jean-Francois,Brion, Jean-Daniel,Messaoudi, Samir,Alami, Mouad
, p. 3808 - 3816 (2014/03/21)
An efficient and general palladium-catalyzed coupling of 3-chloro-quinoxalinones with a variety of nitrogen-containing nucleophiles such as (hetero)aromatic and aliphatic amides as well as some challenging weakly nucleophilic nitrogen compounds including lactams, carbamates and NH-containing azoles is described. In all cases, the reactions take place rapidly and cleanly in dioxane using Pd(OAc)2 as a catalyst, Xantphos as a ligand and K2CO3 as a base furnishing the coupling 3-N-substituted quinoxalinone products in good to excellent yields. This journal is The Royal Society of Chemistry 2013.
