144104-44-9

Basic information

• Product Name: 5-(4-FLUORO-PHENYL)-1H-INDOLE
• Synonyms: AKOS BAR-1284;5-(4-FLUORO-PHENYL)-1H-INDOLE
• CAS NO: 144104-44-9
• Molecular Formula: C₁₄H₁₀FN
• Molecular Weight: 211.23
• Mol File: 144104-44-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 389.1°C at 760 mmHg
• Flash Point: 189.1°C
• Appearance: /
• Density: 1.232g/cm³
• Vapor Pressure: 6.55E-06mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: 5-(4-FLUORO-PHENYL)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-FLUORO-PHENYL)-1H-INDOLE(144104-44-9)
• EPA Substance Registry System: 5-(4-FLUORO-PHENYL)-1H-INDOLE(144104-44-9)

Safety Data

• Hazardous Substances Data: 144104-44-9(Hazardous Substances Data)

Usage

General Description

5-(4-Fluoro-phenyl)-1H-indole is a chemical compound with the molecular formula C14H10FN. It is an indole derivative with a fluorophenyl group attached to the fifth position of the indole ring. 5-(4-FLUORO-PHENYL)-1H-INDOLE is often used in pharmaceutical research and drug development due to its potential biological and medicinal properties. Indole derivatives have been studied for their diverse pharmacological activities, including anti-inflammatory, antiviral, antitumor, and antidepressant effects. The presence of a fluorophenyl group in 5-(4-Fluoro-phenyl)-1H-indole may further enhance its biological activity and make it a promising candidate for the development of novel drugs.

InChI:InChI=1/C14H10FN/c15-13-4-1-10(2-5-13)11-3-6-14-12(9-11)7-8-16-14/h1-9,16H

Upstream product

• 352-33-0 1-Chloro-4-fluorobenzene 
• 144104-59-6 1H-indole-5-boronic acid 
• 10075-50-0 5-bromo-1H-indole 
• 1765-93-1 4-fluoroboronic acid 
• 160874-85-1 2-(4-fluorophenyl)-[1,3,2]-dioxaborolane 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 1181328-32-4 N-benzyl-5-(4-fluorophenyl)indole 
• 1181328-38-0 N-benzyl-5-(4-fluorophenyl)indole-3-carbaldehyde 
• 1181328-78-8 C₂₉H₂₃F₃N₂ 
• 1181328-76-6 C₂₉H₂₃Cl₂FN₂ 
• 1181328-71-1 C₂₉H₂₅FN₂ 
• 1181328-75-5 C₂₉H₂₄F₂N₂ 
• 1181328-73-3 C₂₉H₂₄ClFN₂ 
• 1181331-67-8 C₂₉H₂₃F₃N₂*ClH 
• 1181331-66-7 C₂₉H₂₃Cl₂FN₂*ClH 
• 1181331-65-6 C₂₉H₂₄F₂N₂*ClH 
• 1181331-64-5 C₂₉H₂₄ClFN₂*ClH 
• 1181331-63-4 C₂₉H₂₅FN₂*ClH 

Relevant articles and documents

Microwave-promoted Suzuki reactions of aryl chlorides in aqueous media

(Chemical Equation Presented) The microwave-promoted Suzuki coupling reaction of aryl chlorides with boronic acids performed in an aqueous media was studied using the air- and moisture-stable catalyst POPd2 (dihydrogen di-μ-chlorodichlorobis(di-test-butylphosphinito-κP)dipalladate (2-)). This catalyst system under microwave conditions (150°C, 15 min) provided coupled products with yields ranging from 64% to 99%. This method tolerated a variety of substituents and sterically hindered substrates.

Total synthesis of (±) aspidostomide B, C, regioisomeric N-methyl aspidostomide D and their derivatives

A full account of the total synthesis of aspidostomide B, C, their analogues and our synthetic efforts towards the synthesis of aspidostomide D, which led to the synthesis of regioisomeric N-methyl aspidostomide D, its analogues via epoxide opening strategy is presented. The synthesis of regioisomeric N-methyl aspidostomide D involves an efficient, five-step sequence, with 36.3% overall yield, starting from 3,4,5-tribromo-1H-pyrrole-2-carboxylic acid. The key features of this protocol are intramolecular cyclization, dehydration, oxidation, and a Lewis acid-mediated regioselective epoxide ring opening by C-3 position of 2,5-dibromo-1H-indole to furnish the title compounds.

N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR

The present invention relates to the use compounds of formula I which are antagonists of the 5-HT 6 receptor, for treating a cognitive disorder selected from the group consisting of age-related cognitive decline, mild cognitive impairment and dementia