1441173-84-7Relevant articles and documents
FeCl3-mediated friedel-crafts hydroarylation with electrophilic N-acetyl indoles for the synthesis of benzofuroindolines
Beaud, Rodolphe,Guillot, Regis,Kouklovsky, Cyrille,Vincent, Guillaume
supporting information, p. 12546 - 12550 (2013/02/22)
IRONic electrophilic indoles! The C3-regioselective hydroarylation of N-acetyl indoles with aromatic nucleophiles mediated by FeCl3 features a rare example of the electrophilic reactivity of the indole core in a Friedel-Crafts reaction. This indole umpolung allows us straightforward access to the tetracyclic benzofuroindoline motif found in the natural product diazonamide A, which is a potent antitumor agent. Copyright
