144119-07-3Relevant academic research and scientific papers
Stereoselective Alkylation of Cyclic and Acyclic Chiral β-Enamino Ketones Lithium Dianions: Synthesis of Either (R)- or (S)-Chiral 1,3-Diketones.
Bartoli, Giuseppe,Bosco, Marcella,Cimarelli, Cristina,Dalpozzo, Renato,Munno, Giovanni De,Palmieri, Gianni
, p. 1651 - 1665 (2007/10/02)
The synthesis of either (R)- or (S)-chiral 1,3-diketones through asymmetric γ alkylation reaction of cyclic and acyclic chiral β-enamino ketones was here performed.The alkylation takes place with good yields and high d.e. in HMPA/THF.Both the pure enantiomers of 1,3-diketones can be formed by simple hydrolysis of the epimeric β-enamino ketones obtained with this method, choosing the suitable synthetic strategies.An explanation of the asymmetric induction was proposed.
Stereoselective carbon-carbon bond formation: γ-Alkylation of lithium dianion of chiral cyclic β-enamino ketones
Bartoli,Cimarelli,Palmieri,Rafaiani
, p. 719 - 722 (2007/10/02)
The γ-alkylation of the chiral β-enamino ketones (1) has been obtained with good yields and d.e. on the si face of the lithium dianion intermediate.
