144124-40-3

Upstream product

• 32634-68-7 (2S,3S)-di-4-toluoyltartaric acid 
• 143957-08-8 carbonic acid, ethyl (3S,4R)-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>-4-piperidinyl ester 
• 541-41-3 chloroformic acid ethyl ester 
• 172376-39-5 cis-(+/-)-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>-4-piperidinol 

Relevant academic research and scientific papers

Compositions containing opioid antagonists

Compositions containing opioid antagonists are disclosed, particularly alvimopan and its active metabolite in solid dosage forms, where the drug is uniformly distributed, achieves the desired bioavailability, and is stable. Methods of preparing and using the compositions containing opioid antagonists are also disclosed. The results are achieved by a combination of processing techniques and component selection.

Compositions containing opioid antagonist

Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.