1441317-11-8Relevant articles and documents
Chemoselective hydrosilylation of hydroxyketones
Lage, Marta L.,Bader, Scott J.,Sa-Ei, Kanicha,Montgomery, John
, p. 5609 - 5613 (2013)
A chemoselective method for the hydrosilylation of ketones has been developed, using the combination of triphenylsilane and a catalyst prepared from Ni(COD)2 and the simple N-heterocyclic carbene IMes. The most notable feature of this method is that free hydroxyls are largely unaffected, thus providing a simple one-step procedure for the conversion of hydroxyketones to mono-protected diols, wherein the protecting group is exclusively installed on the ketone-derived hydroxyl. The process is typically high yielding with both simple ketones and more complex hydroxyketone substrates.