144154-99-4 Usage
Chemical Family
Acridinone family
Derivative
Acridine, a heterocyclic organic compound
Potency
Potent anticancer agent
Activities
Demonstrated cytotoxic and antiproliferative activities
Cancer Cell Lines
Inhibits growth of various cancer cell lines, including breast, lung, and prostate cancer cells
Structural Features
Presence of acetyloxy and chloro substituents on the acridinone core
Biological Activity
Acetyloxy and chloro substituents contribute to the compound's biological activity
Research Focus
Being studied for its potential as an anti-cancer drug
Potential Applications
May have applications in cancer therapy
Check Digit Verification of cas no
The CAS Registry Mumber 144154-99-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,1,5 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 144154-99:
(8*1)+(7*4)+(6*4)+(5*1)+(4*5)+(3*4)+(2*9)+(1*9)=124
124 % 10 = 4
So 144154-99-4 is a valid CAS Registry Number.
144154-99-4Relevant academic research and scientific papers
Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures
Kesten, Stephen J.,Degnan, Margaret J.,Hung, Jocelyn,McNamara, Dennis J.,Ortwine, Daniel F.,et al.
, p. 3429 - 3447 (2007/10/02)
To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.
