144155-52-2

Basic information

• Product Name: 7-Chloro-3-(4-chloro-3-trifluoromethyl-phenyl)-1-[(E)-3-dimethylamino-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one
• CAS NO: 144155-52-2
• Molecular Weight: 510.386
• Mol File: 144155-52-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-Chloro-3-(4-chloro-3-trifluoromethyl-phenyl)-1-[(E)-3-dimethylamino-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-3-(4-chloro-3-trifluoromethyl-phenyl)-1-[(E)-3-dimethylamino-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one(144155-52-2)
• EPA Substance Registry System: 7-Chloro-3-(4-chloro-3-trifluoromethyl-phenyl)-1-[(E)-3-dimethylamino-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one(144155-52-2)

Safety Data

• Hazardous Substances Data: 144155-52-2(Hazardous Substances Data)

Upstream product

• 144155-81-7 Sodium; 5-(4-chloro-3-trifluoromethyl-phenyl)-6-ethoxycarbonyl-3-oxo-cyclohex-1-enolate 
• 144128-81-4 5-(4-Chloro-3-trifluoromethyl-phenyl)-cyclohexane-1,3-dione 
• 144155-72-6 4--1-chloro-2-(trifluoromethyl)benzene 
• 34328-46-6 4-chloro-3-(trifluoromethyl)benzaldehyde 
• 445-01-2 5-bromo-2-chlorobenzotrifluoride 
• 4743-17-3 5-Chloroisatoic anhydride 
• 144155-23-7 7-Chloro-3-(4-chloro-3-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 109-55-7 1-amino-3-(dimethylamino)propane 

Relevant articles and documents

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.