144173-85-3

Usage

Uses

Used in Pharmaceutical and Medical Research:
5-(TRIBUTYLSTANNYL)PYRIMIDINE is used as a precursor compound for the development of new pharmaceuticals and medical research. Its unique structure allows for the creation of C-C bonds, which are essential in the synthesis of various organic substances, making it a valuable asset in the discovery and design of novel therapeutic agents.
Used in Organic Chemistry:
In the realm of organic chemistry, 5-(TRIBUTYLSTANNYL)PYRIMIDINE is used as a reagent in palladium-catalyzed cross-coupling reactions. These reactions are crucial for the formation of C-C bonds, which are the backbone of many organic compounds. The tributylstannyl group's ability to be introduced into a molecule makes 5-(TRIBUTYLSTANNYL)PYRIMIDINE a key player in the synthesis of complex organic structures.
Used in Chemical Synthesis:
5-(TRIBUTYLSTANNYL)PYRIMIDINE is used as a building block in the synthesis of various chemical compounds. Its pyrimidine ring and tributylstannyl group provide a versatile platform for the creation of new molecules with potential applications in a wide range of industries, including materials science, agrochemicals, and specialty chemicals.
Used in Research and Development:
In academic and industrial research settings, 5-(TRIBUTYLSTANNYL)PYRIMIDINE is used as a research tool to explore new chemical reactions and mechanisms. Its unique properties and reactivity make it an interesting subject for study, potentially leading to new insights and advancements in the field of chemistry.
Used in Safety and Toxicity Studies:
Given the potential toxicity of organotin compounds, 5-(TRIBUTYLSTANNYL)PYRIMIDINE is also used in studies focused on safety and toxicity. Understanding the effects of 5-(TRIBUTYLSTANNYL)PYRIMIDINE on biological systems is crucial for the development of safe handling procedures and the assessment of its potential risks in various applications.

InChI:InChI=1/C4H3N2.3C4H9.Sn/c1-2-5-4-6-3-1;3*1-3-4-2;/h2-4H;3*1,3-4H2,2H3;/rC16H30N2Sn/c1-4-7-10-19(11-8-5-2,12-9-6-3)16-13-17-15-18-14-16/h13-15H,4-12H2,1-3H3

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 1461-22-9 tributyltin chloride 

Downstream Products

• 802904-70-7 C₂₅H₂₄ClN₃O₂S 
• 2036-41-1 5-methylpyrimidine 
• 842133-96-4 4-methyl-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-[(5-(5-pyrimidyl)-2-thienyl)methyl]benzene 
• 1392840-29-7 1-benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyrimidin-5-yl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid methyl ester 
• 1392840-08-2 1-benzyl-5-hydroxy-2-oxo-3-pyrimidin-5-yl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid methyl ester 
• 1190984-55-4 C₁₅H₁₁FN₄OS 

Relevant academic research and scientific papers

Stille and Suzuki Cross-Coupling Reactions as Versatile Tools for Modifications at C-17 of Steroidal Skeletons – A Comprehensive Study

Herein, we report on a comparative Stille and Suzuki cross-coupling study of steroidal vinyl (pseudo)halides with different boronic acids and tributyltin organyls. Furthermore, we have investigated the “inverse” case of those cross-coupling reactions, i.e., the reaction of a steroidal vinylpinacolatoborane or a tributyltin steroid with various bromides. The development of both methods allows the introduction of different residues at C-17 of steroid skeletons providing access to a broad variety of steroid analogues which are of high interest for biological screenings or natural product synthesis. (Figure presented.).

N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof

Disclosed are N-arylalkyl-thienopyrimidin-4-amines and analogs thereof, represented by the Formula I: wherein Ar, R1, R3, R4, R10-R12 and n are defined herein. The present invention relates to the dis

(BIS)sulfonamide derivatives

The present invention provides (bis) sulfonamide derivatives of formula (I) useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

N-substituted sulfonamide derivatives

The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

Sulphonamide derivatives

Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formulaR1—L—NHSO2R2??Iin whichR1 represents an unsubstituted or substituted aromatic or heteroaromatic group;R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; andL represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring;and pharmaceutically acceptable salts thereof.Also disclosed are compounds of formula I, processes for preparing them and pharmaceutical compositions containing them.