144189-66-2

Basic information

• Product Name: 3-NITROSOBENZAMIDE
• Synonyms: 3-NITROSOBENZAMIDE;Benzamide, 3-nitroso- (9CI)
• CAS NO: 144189-66-2
• Molecular Formula: C7H6N2O2
• Molecular Weight: 150.13
• Product Categories: AMIDE
• Mol File: 144189-66-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 317.5°Cat760mmHg
• Flash Point: 145.8°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 0.000384mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-NITROSOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITROSOBENZAMIDE(144189-66-2)
• EPA Substance Registry System: 3-NITROSOBENZAMIDE(144189-66-2)

Safety Data

• Hazard Codes: C
• Statements: 35-34-22
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 1759 8/PG 2
• WGK Germany: 1
• Hazardous Substances Data: 144189-66-2(Hazardous Substances Data)

Usage

General Description

3-Nitrosobenzamide is an organic compound that belongs to the nitrosoamides class of chemicals. It is a pale yellow crystalline solid that is commonly used as a raw material in the production of pharmaceuticals and dyes. 3-Nitrosobenzamide has been found to exhibit potential antitumor and anticancer properties, making it a subject of research in the development of new chemotherapy drugs. It is also used in various organic synthesis reactions and as a reagent in chemical analysis. However, it is important to handle 3-Nitrosobenzamide with caution due to its potential health hazards and toxic effects if mishandled.

InChI:InChI=1/C7H6N2O2/c8-7(10)5-2-1-3-6(4-5)9-11/h1-4H,(H2,8,10)

Upstream product

• 3544-24-9 3-Aminobenzamide 

Relevant articles and documents

Specific Disulfide Formation in the Oxidation of HIV-1 Zinc Finger Protein Nucleocapsid p7

In vitro oxidation of the HIV-1 nucleocapsid protein p7 by the C-nitroso compound 3-nitrosobenzamide (NOBA) has been investigated. When reconstituted p7 was incubated with NOBA, three disulfide bonds were formed per molecule of p7, Cys 15-Cys 18, Cys 28-Cys 36, and Cys 39-Cys 49. These were identified using the proteolytic enzyme endoproteinase Lys-C and mass spectrometry. When the denatured protein (Apo-p7) was incubated with NOBA, a more random pattern of multiple S-S linkages was found. Oxidation of reconstituted p7 also occurred on treatment with cupric ions (Cu2+), and the same three major disulfide bonds were formed as in the reaction with NOBA. These results suggest the interpretation that the oxidation reaction occurs at the zinc-binding centers while zinc cations are still bound and that the two zinc fingers are not identical in their chemical properties. This latter point is consistent with the independent biological roles reported previously for the two fingers in the viral infection cycle.

Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents

The subject invention provides for novel compounds for inactivating viruses. These compounds include 6-nitroso-1,2-benzopyrone, 3-nitrosobenzamide, 5-nitroso-1(2H)-isoquinolinone, 7-nitroso-1(2H)isoquinolinone, 8-nitroso-1(2H)isoquinolinone. The invention

Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54

The subject invention provides for novel compounds for inactivating viruses. These compounds include 6-nitroso-1,2-benzopyrone, 3-nitrosobenzamide, 5-nitroso-1(2H)-isoquinolinone, 7-nitroso-1(2H)-isoquinolinone, 8-nitroso-1(2H)-isoquinolinone. The inventi