14419-11-5

Basic information

• Product Name: Ornidazole IsoMer (IMpurity)
• Synonyms: Ornidazole IsoMer (IMpurity);1-chloro-3-(2-methyl-4-nitro-1H-imidazol-1-yl)propan-2-ol;Ornidazole Impurity D;Ornidazole Impurity H
• CAS NO: 14419-11-5
• Molecular Formula: C₇H₁₀ClN₃O₃
• Molecular Weight: 219.6256
• Product Categories: Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 14419-11-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 151-153 °C
• Boiling Point: 443.2°Cat760mmHg
• Flash Point: 221.9°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 1.23E-08mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.29±0.20(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: Ornidazole IsoMer (IMpurity)(CAS DataBase Reference)
• NIST Chemistry Reference: Ornidazole IsoMer (IMpurity)(14419-11-5)
• EPA Substance Registry System: Ornidazole IsoMer (IMpurity)(14419-11-5)

Safety Data

• Hazardous Substances Data: 14419-11-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 14419-11-5 differently. You can refer to the following data:
1. An isomeric impurity of Ornidazole, which maintains anti-infective properties.
2. An isomeric impurity of Ornidazole (0688500), which maintains anti-infective properties.

InChI:InChI=1/C7H10ClN3O3/c1-5-9-7(11(13)14)4-10(5)3-6(12)2-8/h4,6,12H,2-3H2,1H3

Upstream product

• 696-23-1 2-methyl-5-nitro-1H-imidazole 
• 106-89-8 epichlorohydrin 
• 696-23-1 2-methyl-4-nitro-1H-imidazole 

Downstream Products

• 16773-51-6 2-methyl-4-nitro-1-(oxiran-2-ylmethyl)-1H-imidazole 
• 139436-01-4 Benzo[1,3]dioxole-5-carbaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139436-03-6 2-Nitro-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139436-05-8 4-Nitro-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139435-93-1 4-Chloro-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139435-91-9 2-chlorobenzaldehyde O-<3-(2-methyl-4-nitro-1-imidazolil)-2-hydroxypropyl> oxime 
• 139435-97-5 2-Methoxy-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139435-95-3 2-Methyl-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139435-94-2 4-Bromo-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139436-00-3 3,4-Dimethoxy-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139436-04-7 3-Nitro-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139435-92-0 3-Chloro-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139435-99-7 2,4-Dimethoxy-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 
• 139435-98-6 4-Methoxy-benzaldehyde O-[2-hydroxy-3-(2-methyl-4-nitro-imidazol-1-yl)-propyl]-oxime 

Relevant articles and documents

Lipase-catalyzed resolution of both enantiomers of Ornidazole and some analogues

The resolution of the enantiomers of the chemotherapeutic Ornidazole (Tiberal) 1a was achieved by acetylation of the racemic compound with vinylacetate in the presence of lipase Amano PS (from Pseudomonas cepacia). The halogen analogues 4a-6a and the corresponding 4-nitro-derivatives 1b and 4b-6b were also synthesized and the enantiomers were separated by kinetic enzymatic resolution. The absolute configuration of two compounds was determined by X-ray crystallography.

2-methyl-4-nitroimidazole derivatives and preparation method thereof, and application of pharmaceutical compositions

The invention provides 2-methyl-4-nitroimidazole derivatives and a preparation method of the 2-methyl-4-nitroimidazole derivatives. Besides, pharmaceutical compositions containing the 2-methyl-4-nitroimidazole derivatives are applicable to treatment of many infectious diseases caused by Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus, Clostridium, Eubacterium, Peptococcus and Peptostreptococcus, Helicobacter pylori, Bacteroides melaninogenicus, Fusobacterium, Capnocytophaga, Bacteroides gingivalis and other sensitive anaerobic bacteria.