144218-62-2

Basic information

• Product Name: 4'',6''-O-benzylidene-6'-N-(benzyloxycarbonyl)-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A
• Synonyms: 4'',6''-O-benzylidene-6'-N-(benzyloxycarbonyl)-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A
• CAS NO: 144218-62-2
• Molecular Weight: 1249.45
• Mol File: 144218-62-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'',6''-O-benzylidene-6'-N-(benzyloxycarbonyl)-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A(CAS DataBase Reference)
• NIST Chemistry Reference: 4'',6''-O-benzylidene-6'-N-(benzyloxycarbonyl)-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A(144218-62-2)
• EPA Substance Registry System: 4'',6''-O-benzylidene-6'-N-(benzyloxycarbonyl)-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A(144218-62-2)

Safety Data

• Hazardous Substances Data: 144218-62-2(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 93070-01-0 4'',6''-O-benzylidene-6'-N:4'-O-carbonyl-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A 

Downstream Products

• 144218-63-3 2''-O-acetyl-4'',6''-O-benzylidene-6'-N-(benzyloxycarbonyl)-2',3'-O-cyclohexylidene-1,3,3''-tri-N-tosylkanamycin A 

Relevant articles and documents

Synthesis of 4'-deoxy-4'-fluorokanamycin A and B

4'-Deoxy-4'-fluorokanamycins A (17) and B (25) have been prepared through fluorinating ring-opening of the D-galacto-3',4'-oxiranes (8 and 21) derived from kanamycin A and B with potassium hydrogenfluoride in ethane-1,2-diol.The mechanism of preponderant formation of the 4'-deoxy-4'-fluoro-D-gluco ( 9 and 22) over the 3'-deoxy-3'-fluoro-D-gulo derivatives was discussed.In the synthesis of 25, the unusual 3',6'-epimine (23) was the main product along with the 4'-deoxy-4'-fluoro derivative.The mechanism of this reaction is also discussed.Both 17 and 25 were active against resistant bacteria producing aminoglycoside-adenylylating enzymes for HO-4'.