1442196-75-9Relevant academic research and scientific papers
High control, fast growth OEG-based dendron synthesis via a sequential two-step process of copper-free diazo transfer and click chemistry
Fransen, Peter,Pulido, Daniel,Sevrin, Chantal,Grandfils, Christian,Albericio, Fernando,Royo, Miriam
, p. 2585 - 2591 (2014/05/06)
Dendrons up to generation 3 were quickly synthesized using two sequential steps of diazo transfer and click chemistry reactions. The building blocks for dendron synthesis were made by incorporating monodisperse oligoethylene glycol (OEG) chains of exact length onto diethyelenetriaminepentaacetic acid (DTPA)-derived moieties to obtain first-generation dendrons. Afterward, the amine groups of the first-generation core dendron were converted to azides by means of the diazo transfer reaction. The second- and third-generation dendrons were constructed using the copper-catalyzed azide-alkyne cycloaddition (CuAAC). Hemocompatibility studies including hemolysis, red blood cell morphology, cell count and size distribution, hemostasis, and complement system activation were performed to evaluate their safety in blood.
Biocompatible, multifunctional, and well-defined OEG-based dendritic platforms for biomedical applications
Simón-Gracia, Lorena,Pulido, Daniel,Sevrin, Chantal,Grandfils, Christian,Albericio, Fernando,Royo, Miriam
, p. 4109 - 4121 (2013/07/11)
Given the growing importance of drug and gene delivery systems, imaging agents, biosensors, and theranostics, there is a need to develop new multifunctional and biocompatible platforms. Here we synthesized and fully characterized a family of novel multifu
