144225-41-2

Upstream product

• 144225-40-1 (E)-(S)-7-((1R,5S,6S)-6-Benzyloxymethyl-5-isopropyl-2,2-dimethyl-cyclohexyl)-5-hydroxy-3-oxo-hept-6-enoic acid tert-butyl ester 
• 144225-29-6 Carvomenthon 
• 69153-92-0 (5R)-5-isopropenyl-2,2-dimethylcyclohexanone 
• 144225-30-9 ((S)-3-Isopropyl-6,6-dimethyl-cyclohex-1-enyloxy)-trimethyl-silane 
• 144225-31-0 (5S,6R)-6-Benzyloxymethyl-5-isopropyl-2,2-dimethyl-cyclohexanone 
• 144225-35-4 (E)-3-((1R,5S,6S)-6-Benzyloxymethyl-5-isopropyl-2,2-dimethyl-cyclohexyl)-propenal 
• 144225-39-8 (E)-(S)-5-((1R,5S,6S)-6-Benzyloxymethyl-5-isopropyl-2,2-dimethyl-cyclohexyl)-3-hydroxy-pent-4-enoic acid methyl ester 
• 144225-38-7 (E)-(S)-5-((1R,5S,6S)-6-Benzyloxymethyl-5-isopropyl-2,2-dimethyl-cyclohexyl)-3-hydroxy-pent-4-enoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester 
• 144225-34-3 (1R,5S,6S)-6-Benzyloxymethyl-5-isopropyl-2,2-dimethyl-cyclohexanecarbaldehyde 

Downstream Products

• 144225-44-5 {(4R,6S)-6-[(E)-2-((1R,5S,6S)-6-Hydroxymethyl-5-isopropyl-2,2-dimethyl-cyclohexyl)-vinyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-acetic acid tert-butyl ester 
• 144225-47-8 (3R,5R)-7-[(1R,5S,6S)-6-(2,2-Dimethyl-butyryloxymethyl)-5-isopropyl-2,2-dimethyl-cyclohexyl]-3,5-dihydroxy-heptanoic acid tert-butyl ester 
• 144225-46-7 (E)-(3R,5S)-7-[(1R,5S,6S)-6-(2,2-Dimethyl-butyryloxymethyl)-5-isopropyl-2,2-dimethyl-cyclohexyl]-3,5-dihydroxy-hept-6-enoic acid tert-butyl ester 
• 144225-45-6 2,2-Dimethyl-butyric acid (1S,2R,6S)-2-[(E)-2-((4S,6R)-6-tert-butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-vinyl]-6-isopropyl-3,3-dimethyl-cyclohexylmethyl ester 
• 144225-27-4 Lithium; (3R,5R)-7-[(1R,5S,6S)-6-(2,2-dimethyl-butyryloxymethyl)-5-isopropyl-2,2-dimethyl-cyclohexyl]-3,5-dihydroxy-heptanoate 
• 144225-28-5 Lithium; (E)-(3R,5S)-7-[(1R,5S,6S)-6-(2,2-dimethyl-butyryloxymethyl)-5-isopropyl-2,2-dimethyl-cyclohexyl]-3,5-dihydroxy-hept-6-enoate 
• 144225-43-4 {(4R,6S)-6-[(E)-2-((1R,5S,6S)-6-Benzyloxymethyl-5-isopropyl-2,2-dimethyl-cyclohexyl)-vinyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-acetic acid tert-butyl ester 
• 144225-42-3 Lithium; (E)-(3R,5S)-7-((1R,5S,6S)-6-benzyloxymethyl-5-isopropyl-2,2-dimethyl-cyclohexyl)-3,5-dihydroxy-hept-6-enoate 

Relevant academic research and scientific papers

C-2 Dimethyl seco-Mevinic Acids. Synthesis of Monocyclic HMG-CoA Reductase Inhibitors from (R)-(-)-Carvone

An efficient preparation of novel monocyclic HMG-CoA reductase inhibitors from (R)-(-)-carvone is reported.Utilizing this chiral carbon pool, the C-2 dimethyl seco-mevinic acid 3a was prepared in 17 steps and 5.2percent overall yield.The key chiral intermediate aldehyde 10a was prepared via a short and efficient synthetic sequence (six steps, 27percent yield) from (R)-(-)-carvone.The appropriate chirality of the diol acid side chain was secured by employing the chiral acetate synthon "(S)-HYTRA" and by performing a stereoselective 1,3-syn reduction on the β-hydroxy ketone 19.Structural requirements at the C-2 position are rather stringent, and deletion of or addition of an extra methyl group are both unacceptable modifications for this novel class of monocyclic HMG-CoA reductase inhibitors.