144239-99-6

Upstream product

• 331767-03-4 tert-butyl (1S,2R,4S)-4-amino-1-benzyl-2-hydroxy-5-phenylpentylcarbamate 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 482647-80-3 tert-butyl (1S,2R,4S)-4-azido-1-benzyl-2-hydroxy-5-phenylpentylcarbamate 
• 331766-97-3 tert-butyl (1S,2R,4R)-1-benzyl-2,4-dihydroxy-5-phenylpentylcarbamate 
• 331767-01-2 Methanesulfonic acid (R)-1-benzyl-2-((4S,5R)-4-benzyl-2-oxo-oxazolidin-5-yl)-ethyl ester 
• 331767-00-1 (4S,5R)-4-benzyl-5-[(2R)-2-hydroxy-3-phenylpropyl]-1,3-oxazolidin-2-one 
• 331767-02-3 (4S,5R)-4-benzyl-5-[(2S)-2-azido-3-phenylpropyl]-1,3-oxazolidin-2-one 
• 198208-08-1 (4R,5S)-5-[N-(tert-butyloxycarbonyl)amino]-4-hydroxy-1,6-diphenyl-2-hexene 
• 198208-15-0 (2R,3R,4S,5S)-5-[N-(tert-butyloxycarbonyl)amino]-2,3-epoxy-4-hydroxy-1,6-diphenylhexane 
• 198208-01-4 (S,E)-tert-butyl 3-oxo-1,6-diphenylhex-4-en-2-ylcarbamate 
• 176504-90-8 dimethyl [(3S)-4-phenyl-3-[N-(tert-butyloxycarbonyl)amino]-2-oxobutyl]phosphonate 

Relevant academic research and scientific papers

Synthesis and antimycobacterial activity of novel amino alcohols containing central core of the anti-HIV drugs lopinavir and ritonavir

Eleven new amino alcohol derivatives have been synthesized from reactions of lopinavir intermediate and heteroaromatic aldehyde in good yields. These compounds, the antiretrovirals (lopinavir and ritonavir) and lopinavir key intermediate were evaluated as

Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases

We have extended a highly flexible method for rapidly assembling aspartic protease inhibitors to produce symmetric and asymmetric monohydroxyethylene peptidomimetics. This method is based on the prior synthesis of the central non-cleavable peptide-bond is