144242-89-7

Basic information

• Product Name: 1-<2-(benzylthio)phenyl>piperazine
• CAS NO: 144242-89-7
• Molecular Weight: 284.425
• Mol File: 144242-89-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-<2-(benzylthio)phenyl>piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<2-(benzylthio)phenyl>piperazine(144242-89-7)
• EPA Substance Registry System: 1-<2-(benzylthio)phenyl>piperazine(144242-89-7)

Safety Data

• Hazardous Substances Data: 144242-89-7(Hazardous Substances Data)

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 100-44-7 benzyl chloride 
• 2071-85-4 N-bis(2-bromoethyl)amine hydrochloride 
• 6325-92-4 2-(benzylsulfanyl)aniline 

Relevant articles and documents

Synthesis and Biological Activity of 4-(Diphenylmethyl)-α--1-piperazineethanol and Related Compounds

A series of 4-(diphenylmethyl)-α--1-piperazineethanol and closely related compounds was synthesised and evaluated for cardiac and vascular activity in isolated perfused rat and guinea pig hearts.Compound 1 produced greater inotropic effects in rat hearts than in guinea pig hearts, a phenomenon which was also observed with the prototype agent DPI 201-106.Compound 15 produced an inotropic effect with one-tenth the potency of compound 1.Both compounds 1 and 15 demonstrated direct inotropic and vasodilatory effects when administered iv in anesthetized dogs, although the vasodilatory activity was more pronounced with compound 15 than 1 and DPI compound.Compound 1 lacks the CN moiety which is a key structural requirement in DPI for positive inotropic activity.The synthesis, in vitro, and in vivo evaluations of these agents, and comparative data with DPI-201-106 (compound 17) are reported.