144265-47-4

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 198197-91-0 Trimethyl-[4-methyl-2-(tetrahydro-pyran-2-yloxy)-phenyl]-silane 
• 108-39-4 3-methyl-phenol 
• 914094-53-4 2-(3-(bromomethyl)phenoxy)tetrahydro-2H-pyran 
• 259209-25-1 (2-hydroxy-4-methylphenyl)boronic acid 
• 189574-85-4 (E)-ethyl 3-(2-hydroxy-4-methylphenyl)acrylate 

Relevant academic research and scientific papers

Supported N-propylsulfamic acid onto Fe3O4 magnetic nanoparticles as a reusable and efficient nanocatalyst for the protection/deprotection of hydroxyl groups and protection of aldehydes

N-propylsulfamic acid supported onto Fe3O4 magnetic nanoparticles (MNPs-PSA) as an efficient and magnetically reusable nanocatalyst has been reported for the tetrahydropyranylation/depyranylation of a wide variety of alcohols and phenols by changing the solvent medium. Also, the protection of aldehydes as acylals using Ac2O in the presence of catalytic amount MNPs-PSA in good to high yields at room temperature under solvent-free conditions is described. After completing the reaction, the catalyst was easily separated from the reaction mixture with the assistance of an external magnetic field and reused for several consecutive runs without significant loss of their catalytic efficiency.

Pyrrolopyrazole derivative, preparation method and medical application thereof

The invention relates to pyrrolopyrazole derivatives, a preparation method and application thereof in medicines. Specifically, the invention relates to a new pyrrolopyrazole derivative as shown in a general formula (I), a preparation method thereof and application of the pyrrolopyrazole derivative or a pharmaceutical composition containing the pyrrolopyrazole derivative as a therapeutic agent, particularly as a gastric acid secretion inhibitor and potassium-competitive acid blockers (P-CABs) in biological medicines. Specifically, the substituents (R1, R2, R3 and R4) in the general formula (I)are the same as the definitions in the specification.

Pyrrolopyrazole derivative, preparation method and medical application thereof

The invention relates to pyrrolopyrazole derivative, a preparation method and application thereof in medicines. Specifically, the invention relates to a new pyrrolopyrazole derivative as shown in a general formula (I), a preparation method and application of the pyrrolopyrazole derivative or a pharmaceutical composition containing the pyrrolopyrazole derivative as a therapeutic agent, particularlyas a gastric acid secretion inhibitor and potassium-competitive acid blockers (P-CABs) in biological medicines. Specifically, the substituents (R1, R2, R3 and R4) in the general formula (I) are the same as the definitions in the specification.

CRYSTALLINE ANTI-TRICHOPHYTON AGENTS AND PREPARATION PROCESS THEREOF

A crystal form of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol which is stable and has high purity for preservation, industrial manufacturing, and circulation, and process for providing the same by using a boron compound.

Selective tetrahydropyranylation of alcohols and phenols using titanium(IV) salophen trifluoromethanesulfonate as an efficient catalyst

Titanium(IV) salophen trifluoromethanesulfonate, [TiIV(salophen)(OSO2CF3)2], as a catalyst enables selective tetrahydropyranylation of alcohols and phenols with 3,4-dihydro-2H-pyran. Using this catalytic system, primary, secondary and tertiary alcohols, as well as phenols, were converted to their corresponding tetrahydropyranyl ethers in high yields and short reaction times at room temperature. Investigation of the chemoselectivity of this method showed discrimination between the activity of primary alcohols in the presence of secondary and tertiary alcohols and phenols. This heterogenized catalyst could be reused several times without loss of its catalytic activity. Copyright

Efficient tetrahydropyranyl and tetrahydrofuranyl protection/deprotection of alcohols and phenols with Al(OTf)3 as catalyst

A simple and efficient method for the conversion of alcohols and phenols into their corresponding THP and THF ethers at room temperature has been developed using 1 mol % aluminium triflate as catalyst. The deprotection reaction in the presence of methanol using Al(OTf)3 was equally successful and could be performed at ambient temperature in high yields.

Tetrahydropyranylation of alcohols over modified zeolites

A catalytic amount of Moβ enables tetrahydropyranylation of various alcohols, phenols and naphthols under mild reaction conditions at room temperature in moderate to excellent yields within short reaction times is presented. The catalyst Moβ is reused without significant loss of activity. The product isolation is simple and environmentally benign.

Microwave-assisted preparation of imidazolium-based tetrachloroindate(III) and their application in the tetrahydropyranylation of alcohols

Microwave-assisted preparation of 1-alkyl-3-methylimidazolium tetrachloroindate(III), [Rmim][InCl4] (R = methyl, ethyl, butyl, hexyl, octyl) and their application as recyclable catalysts for the efficient and eco-friendly protection of alcohols to form tetrahydropyranyl (THP) ethers are described.

A novel and efficient method for the synthesis of tetrahydropyranyl ethers catalyzed by Sc(OTf)3

Reaction of alcohols with dihydropyran in the presence of a catalytic amount of Sc(OTf)3 provides efficiently the corresponding tetrahydropyranyl ethers. After the reaction, the catalyst can be recovered quantitatively from the aqueous media and reused without loss of the activity.

Facile Synthesis of 2-Hydroxy-6-methylbenzaldehyde, an Alarm and Sex Pheromone Component of Astigmatid Mites

2-Hydroxy-6-methylbenzaldehyde (5) is a component of astigmatid mites, functioning as the alarm and sex pheromones, and the establishment of its convenient synthesis is prerequisite and of vital importance to develop applications of these pheromones for p