1442652-35-8Relevant articles and documents
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity
Battilocchio, Claudio,Poce, Giovanna,Alfonso, Salvatore,Porretta, Giulio Cesare,Consalvi, Sara,Sautebin, Lidia,Pace, Simona,Rossi, Antonietta,Ghelardini, Carla,Di Cesare Mannelli, Lorenzo,Schenone, Silvia,Giordani, Antonio,Di Francesco, Luigia,Patrignani, Paola,Biava, Mariangela
, p. 3695 - 3701 (2013/07/25)
We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.