14428-55-8

Basic information

• Product Name: 3-acetylphenyl thiocyanate
• Synonyms: 3-acetylphenyl thiocyanate
• CAS NO: 14428-55-8
• Molecular Weight: 177.227
• Mol File: 14428-55-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-acetylphenyl thiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetylphenyl thiocyanate(14428-55-8)
• EPA Substance Registry System: 3-acetylphenyl thiocyanate(14428-55-8)

Safety Data

• Hazardous Substances Data: 14428-55-8(Hazardous Substances Data)

Upstream product

• 540-72-7 sodium thiocyanide 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 40897-44-7 Di(m-acetylphenyl)disulfid 
• 151-50-8 potassium cyanide 

Downstream Products

• 56773-33-2 1-(3-((trifluoromethyl)thio)phenyl)ethan-1-one 

Relevant articles and documents

Synthesis of difluoromethyl thioethers from difluoromethyl trimethylsilane and organothiocyanates generated in situ

A copper-CF2H complex generated in situ from copper thiocyanate and TMS-CF2H smoothly converts organothiocyanates into valuable difluoromethyl thioethers. This reaction step can be combined with several thiocyanation methods to one-pot protocols, allowing late-stage difluoromethylthiolations of widely available alkyl halides and arenediazonium salts. This strategy enables the introduction of difluoromethylthio groups - a largely unexplored substituent with highly promising properties - into drug-like molecules. A copper-CF2H complex generated in situ from copper thiocyanate and TMS-CF2H smoothly converts organothiocyanates into valuable difluoromethyl thioethers. This reaction step can be combined with several thiocyanation methods to one-pot protocols, allowing late-stage difluoromethylthiolations of widely available alkyl halides and arenediazonium salts.