144290-89-1

Usage

Physical state at room temperature

Blue solid

Common uses

Synthesis of pharmaceuticals and agrochemicals

Core structure

Dihydrobenzisoxazolone

Side chain

Nitrophenyl

Functional groups

Aromatic and nitro

Role in organic synthesis

Building block

Role in coordination chemistry

Ligand

Potential applications

Medicine, agriculture, and chemical research

Importance

Significant chemical in various industries due to its properties and uses

Upstream product

• 35447-75-7 N-hydroxy-2-nitrobenzimidoyl chloride 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 104675-26-5 9-Amino-1,2,3,4-tetrahydroacridin-1-one 

Relevant academic research and scientific papers

Heterocycle-to-heterocycle route to quinoline-4-amines: Reductive heterocyclization of 3-(2-nitrophenyl)isoxazoles

A variety of quinoline-4-amines were synthesized from substituted 3-(2-nitrophenyl)isoxazoles utilizing Zn0 or Fe0 dust and HOAc using a reductive heterocyclization process. The starting isoxazoles were synthesized from readily available starting materials. A brief survey of functional groups tolerated in this reductive heterocyclization was performed and several 10-amino-3,4-dihydrobenzo[b][1,6]naphthyridin-1(2H)-one and 9-amino-3,4-dihydroacridin-1(2H)-one examples were synthesized.

9-aminotetrahydroacridines and related compounds

Novel 9-aminotetrahydroacridines and related compounds, intermediates and processes for the preparation thereof, and a method of relieving memory dysfunction are disclosed.