144297-32-5Relevant academic research and scientific papers
Grignard additions to α,β-unsaturated dioxolanones: Preparation of chiral allylic alcohols and protected α-hydroxy aldehydes
Heckmann,Mioskowski,Bhatt, Rama K.,Falck
, p. 1421 - 1424 (2007/10/03)
α,β-Unsaturated dioxolanones derived from mandelic acid smoothly add most Grignard reagents with good to excellent regio- and diastereoselectivities. The adducts are converted to chiral secondary alcohols by peroxidation at low temperature or to protected α-hydroxy aldehydes via ozonolysis.
Oxidative decarboxylation of mandelate ethers and α-substituted phenylacetates via dioxetanone generation
Heckmann,Alayrac,Mioskowski,Chandrasekhar,Falck
, p. 5205 - 5208 (2007/10/02)
Mandelate ethers are oxidatively decarboxylated via in situ generated dioxetanones using (t)BuOK and air at ambient temperature leading, after hydrolysis, to the benzoic acid and the corresponding alcohol. The reaction can be extended to α-substituted phenylacetates.
