1443005-66-0

Basic information

• Product Name: 5(R)-(isoxazol-3-yl-N-(tert-butoxycarbonyl)aminomethyl)-3-(3-fluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one
• Synonyms: 5(R)-(isoxazol-3-yl-N-(tert-butoxycarbonyl)aminomethyl)-3-(3-fluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one
• CAS NO: 1443005-66-0
• Molecular Weight: 710.76
• Mol File: 1443005-66-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5(R)-(isoxazol-3-yl-N-(tert-butoxycarbonyl)aminomethyl)-3-(3-fluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5(R)-(isoxazol-3-yl-N-(tert-butoxycarbonyl)aminomethyl)-3-(3-fluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one(1443005-66-0)
• EPA Substance Registry System: 5(R)-(isoxazol-3-yl-N-(tert-butoxycarbonyl)aminomethyl)-3-(3-fluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one(1443005-66-0)

Safety Data

• Hazardous Substances Data: 1443005-66-0(Hazardous Substances Data)

Upstream product

• 1138150-46-5 [1,2,5]triazepane-1-carboxylic acid tert-butyl ester 
• 264600-97-7 3-N-(t-butoxycarbonyl)amino-1,2-isoxazole 
• 952150-17-3 5(R)-(hydroxymethyl)-3-(3-fluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one 
• 1443005-33-1 5-(4-benzyloxycarbonylamino-2-fluorophenyl)[1,2,5]triazepane-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 1443005-30-8 5-(2-fluoro-4-nitrophenyl)[1,2,5]triazepane-1-carboxylic acid tert-butyl ester 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 1443005-69-3 5(R)-(isoxazol-3-yl-N-(tert-butoxycarbonyl)aminomethyl)-3-(3-fluoro-4-(1-(tert-butoxycarbonyl) [1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one 
• 1139351-39-5 5(S)-(isoxazol-3-yl-aminomethyl)-3-(3-fluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one 

Relevant articles and documents

Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit

We synthesized a series of oxazolidinone analogues bearing a N-hydroxyacetyl-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit as homologues of an earlier drug candidate, eperezolid. Several of these compounds exhibited potent in vitro antibacterial activities towards not only Gram-positive, but also Gram-negative and linezolid-resistant pathogens. Compounds 21a and 21b, bearing a thiocarbamate side chain, showed high in vivo activity against methicillin-resistant Staphylococcus aureus SR3637, together with a promising safety profile in terms of weak inhibition of monoamine oxidase and cytochrome P450 isozymes.